Research Keyword: drug susceptibility testing

Disseminated subcutaneous sporotrichosis in an immunocompetent patient: A case report and a systematic literature review

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A 74-year-old man developed multiple infected lumps on his arm, wrist, and finger months after being injured by a tree branch. Doctors identified the infection as sporotrichosis caused by a fungus called Sporothrix schenckii using advanced genetic testing. He was successfully treated with itraconazole tablets for several months and completely recovered. This case is unusual because sporotrichosis typically affects people with weakened immune systems, but this patient had a normal immune system.

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Superficial abdominal surgical site infection caused by Aspergillus welwitschiae: a case report

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An elderly woman developed a rare fungal infection in her abdominal surgical wound after surgery for a perforated colon. The infection was caused by Aspergillus welwitschiae, a mold that was initially thought to be a more common species. Doctors treated the infection by surgically removing the infected tissue and giving the patient an antifungal medication called voriconazole. This is the first reported case of this particular mold causing this type of surgical infection.

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Invasive fungal otitis media with peripheral facial paralysis

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This case describes a rare fungal ear infection caused by Aspergillus fumigatus that spread to the mastoid bone and caused facial nerve paralysis. The patient had ear drainage and hearing loss for 4 years before diagnosis. Treatment required two surgical procedures to remove infected tissue combined with 6 months of antifungal medication, eventually resulting in healing and recovery of facial nerve function.

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Eikenella corrodens isolated from pleural effusion: A case report

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A 67-year-old patient developed a severe lung infection called empyema caused by a rare bacterium called Eikenella corrodens. Doctors drained infected fluid from the patient’s lungs and identified the bacterium through laboratory testing using special culture techniques and chemical tests. The patient received antibiotics but unfortunately died after 22 days despite treatment. This case highlights the importance of extended laboratory testing and improved diagnostic capabilities in hospitals to identify rare bacteria.

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Investigating the Increasing Azole Resistance in Candida Infections Among Critically Ill Patients: Experience From a Tertiary-Level Setup in North India

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This study tracked the increase in drug-resistant yeast infections in hospitalized patients in India from 2023 to 2025. The researchers found that common antifungal medications like fluconazole are becoming less effective, with resistance rates nearly doubling over the study period. The good news is that newer antifungal drugs called echinocandins remained highly effective. The findings highlight the need for better infection control measures and more careful use of antifungal medications.

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Trichosporon Urinary Tract Infections: A Hidden Menace Revealed

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Trichosporon is a fungus that causes urinary tract infections primarily in hospitalized patients and those with weakened immune systems. This review found that Trichosporon asahii is the most common species responsible for these infections, especially in patients with prolonged hospital stays or using immunosuppressive medications. The drug voriconazole works best against this fungus, while some common antifungal medications like amphotericin B are less effective. Accurate identification using modern laboratory techniques is crucial for proper treatment.

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In Vitro Activity of Nitroxoline (5-Nitro-8-Hydroxyquinoline) Against Aspergillus Species

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Researchers tested an old antibiotic called nitroxoline against Aspergillus fungi that cause serious infections in immunocompromised patients. The drug works by removing zinc that the fungus needs to survive. The study found that nitroxoline was very effective against all tested fungal strains, including those resistant to modern antifungal drugs, suggesting it could potentially be repurposed as a new treatment option.

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