Research Keyword: drug susceptibility

Peritoneal dialysis-related peritonitis caused by Fusarium: a case report and literature review

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A 61-year-old farmer on peritoneal dialysis developed a rare fungal infection caused by Fusarium after antibiotics failed to treat her peritonitis. Pharmacists helped doctors switch her to the antifungal medication voriconazole and carefully monitored blood levels to ensure the dose was high enough. After adjusting the dose based on blood tests, the patient recovered completely with no symptoms and normal test results within two months.

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John Perfect Shares Insights on Infectious Diseases, Antifungal Therapy, and Drug Resistance

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This interview with Dr. John Perfect, a leading expert in fungal infections, discusses how antifungal treatments have evolved over his 48-year career. He explains that while fungal resistance is a concern, it’s less problematic than bacterial antibiotic resistance because fungi don’t spread resistance through plasmids. Dr. Perfect emphasizes the importance of newer, faster-acting antifungal drugs and combining drug therapy with immune system support to better treat serious fungal infections like cryptococcal meningitis and candidemia.

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A case of rare fungal keratitis caused by Pseudoshiraia conidialis

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A 61-year-old woman scratched her eye with a bamboo branch and developed a serious fungal eye infection caused by a rare fungus called Pseudoshiraia conidialis. This is the first reported case of this particular fungus infecting human eyes. Although initial treatment with antifungal medications showed promise, the infection proved difficult to cure due to the fungus being resistant to multiple antifungal drugs. The case highlights the importance of early diagnosis and treatment of fungal eye infections.

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Tracing the Origin and Evolution of the Fungal Mycophenolic Acid Biosynthesis Pathway

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Mycophenolic acid is an important drug that helps transplant patients by preventing their immune systems from rejecting new organs. Scientists studied the genes that fungi use to make this drug and found it in several fungal species. They discovered that this ability to produce the drug evolved a long time ago in fungi but was lost in most species over time, remaining only in a few special fungi.

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