Research Keyword: Drug-resistant fungal infection

Trichophyton indotineae Infection, São Paulo, Brazil, 2024

mycolabadmin

A businessman from São Paulo, Brazil contracted a difficult-to-treat fungal skin infection caused by Trichophyton indotineae, which is resistant to the common antifungal drug terbinafine. After terbinafine failed to help over 9 weeks, doctors switched him to itraconazole, which worked well after 8 weeks. Genetic testing showed his fungal strain had a specific resistance mutation and was most similar to a strain from Germany, suggesting he may have caught it while traveling in Europe.

Read More »

Antifungal activity and mechanism of novel peptide Glycine max antimicrobial peptide (GmAMP) against fluconazole-resistant Candida tropicalis

mycolabadmin

Scientists developed a new antimicrobial peptide called GmAMP that can effectively kill drug-resistant fungal infections caused by Candida tropicalis, a pathogen resistant to common antifungal medications. The peptide works by damaging the fungal cell membrane and is safe for human use. In laboratory tests using insect larvae, the peptide successfully treated infections and reduced the fungal burden, suggesting it could become a new treatment option for patients with resistant fungal infections.

Read More »

Antimicrobial effects and mechanisms of hydrogen sulphide against nail pathogens

mycolabadmin

Researchers discovered that hydrogen sulphide (H2S), a small gas molecule, can effectively kill the fungi and bacteria that cause painful nail infections. Unlike current treatments that struggle to penetrate into the nail, hydrogen sulphide easily diffuses through the nail plate. The study found that H2S works by damaging the fungi’s respiratory system and creating harmful reactive oxygen species, while also modifying proteins in a way that disrupts their normal function. This innovative approach could offer patients a new topical treatment option for nail infections that have been difficult to treat with existing medications.

Read More »

Successful management of Lomentospora prolificans septic arthritis and osteomyelitis in an immunocompetent child: A case report

mycolabadmin

A 3-year-old healthy child developed a serious fungal bone and joint infection in the elbow after surgery to repair a broken arm bone. The fungus, called Lomentospora prolificans, is extremely resistant to most medications and can lead to limb amputation. Doctors saved the child’s arm by combining multiple approaches: repeated surgeries to clean out infected tissue, three different antifungal medications taken together, special antibiotic-loaded bone cement placed in the elbow, and antiseptic wound washing. After six months of treatment, the infection was cured and the child could use their arm again.

Read More »
Scroll to Top