drug resistance – mycolab.ai

The Potential of Mushroom Extracts to Improve Chemotherapy Efficacy in Cancer Cells: A Systematic Review

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This systematic review examines how mushroom extracts can make chemotherapy more effective at treating cancer, particularly by helping overcome cancer cells’ resistance to drugs. Researchers found that various mushroom species contain compounds that work together with chemotherapy drugs to kill cancer cells more effectively through different cellular mechanisms. The results suggest mushroom extracts could be a promising natural complement to conventional cancer treatments, though more research is needed before they can be used clinically.

Therapeutic Effects of Natural Products on Liver Cancer and Their Potential Mechanisms

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This review examines how natural products from plants, fungi, and marine organisms can help treat liver cancer more safely and effectively than current drugs. These natural compounds work through multiple pathways such as triggering cancer cell death, stopping cell growth, and boosting the immune system. The research found that seven categories of natural products show promise, with sources ranging from ginseng and turmeric to mushrooms and seaweed, offering potential new treatment options that could reduce side effects and drug resistance.

Ganoderma lucidum methanolic extract as a potent phytoconstituent: characterization, in-vitro antimicrobial and cytotoxic activity

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Researchers tested a medicinal mushroom extract (Reishi/Ganoderma lucidum) to see if it could fight cancer and bacterial infections. The extract showed promising results, being particularly effective against blood cancer and breast cancer cells while being less toxic to normal healthy cells. It also killed bacteria better than some standard antibiotics, suggesting it could potentially be developed into a new type of medicine for treating cancer and infections.

Baicalein as a potent antifungal agent against Candida albicans: synergy with fluconazole and sustainable production through probiotic-mediated bioconversion

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Baicalein, a natural compound from a traditional medicinal plant, is significantly more effective at fighting Candida albicans infections than its parent compound baicalin. When combined with the common antifungal drug fluconazole, baicalein creates a powerful synergistic effect that is especially useful against drug-resistant fungal strains. Scientists discovered that a beneficial probiotic bacterium, Lactobacillus rhamnosus, can efficiently convert the abundant baicalin into baicalein, providing a sustainable and safe way to produce this potent antifungal compound at scale.

Clinical Isolate of Candida tropicalis from a Patient in North Carolina: Identification, Whole-Genome Sequence Analysis, and Anticandidal Activity of Ganoderma lucidum

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Researchers in North Carolina identified a drug-resistant yeast infection (Candida tropicalis) from a hospital patient and tested whether extracts from reishi mushrooms (Ganoderma lucidum) could kill it. Using genetic analysis, they found mutations in the yeast that help it resist antifungal drugs. All three types of mushroom extracts tested successfully stopped the yeast’s growth and damaged its cells, suggesting that reishi mushrooms could be a promising natural treatment option for hard-to-treat candida infections.

Recent Advances in the Use of Ganoderma lucidum and Coriolus versicolor Mushrooms to Enhance the Anticancer Efficacy of EGFR-Targeted Drugs in Lung Cancer

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This review explores how two medicinal mushrooms traditionally used in Asian medicine—Lingzhi and Yunzhi—can enhance the effectiveness of lung cancer drugs (EGFR-TKIs) and help overcome drug resistance. These mushrooms contain special compounds that can fight cancer in multiple ways, boost the immune system, and reduce side effects. The research suggests that combining these mushrooms with standard cancer treatments may improve outcomes for lung cancer patients.

Green-Synthesized Nanomaterials from Edible and Medicinal Mushrooms: A Sustainable Strategy Against Antimicrobial Resistance

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Scientists are developing a new weapon against antibiotic-resistant bacteria using mushrooms. These special nanoparticles derived from edible and medicinal mushrooms can kill harmful bacteria in multiple ways without the toxic chemicals used in traditional manufacturing. The nanoparticles work by disrupting bacterial membranes, creating harmful molecules called free radicals, and even boosting your body’s natural immune response. This environmentally friendly approach could become an important tool in fighting dangerous infections that don’t respond to current antibiotics.

One-Health Approach to Managing Aflatoxin-Producing Aspergillus flavus Using Spent Mushroom Substrate of Pleurotus spp

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This study shows that leftover substrate from growing oyster and red mushrooms can work together with a common antifungal fungicide to better prevent harmful Aspergillus fungi from contaminating corn. The combination of mushroom waste and fungicide was more effective than using either alone, and could potentially reduce the amount of chemicals needed in agriculture while protecting the environment and preventing drug resistance.

Advances in Fungal Infection Research: From Novel Diagnostics to Innovative Therapeutics

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Fungal infections are becoming increasingly serious, especially for people with weakened immune systems, and some fungi are developing resistance to current medications. Researchers are developing faster diagnostic tests using molecular techniques and exploring new treatment approaches including repurposing existing drugs and developing vaccines. Monitoring and prevention programs in hospitals are essential to control the spread of these infections and improve patient outcomes.

Impact of Clove Oil on Biofilm Formation in Candida albicans and Its Effects on Mice with Candida Vaginitis

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This research demonstrates that clove oil, a natural and FDA-approved dietary supplement, can effectively combat Candida albicans infections that cause vaginal yeast infections. The study found that clove oil works by preventing the fungus from forming protective biofilms and by reducing inflammation. In mice with vaginal yeast infections, clove oil treatment significantly improved symptoms and reduced fungal levels, suggesting it could serve as a safer alternative to conventional antifungal medications.

Research Keyword: drug resistance