drug interactions – mycolab.ai

Simultaneous cannabis and psychedelic use among festival and concert attendees in Colorado: characterizing enhancement and adverse reactions using mixed methods

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This study surveyed music festival and concert attendees in Colorado about their experiences using cannabis and psychedelics together. Researchers found that most people reported cannabis made their psychedelic experience better by reducing anxiety, enhancing mood, or intensifying effects. Only a small percentage experienced negative effects like increased anxiety or confusion. The study suggests cannabis may help people manage difficult psychedelic trips, though more research is needed to understand how different types and amounts of cannabis affect outcomes.

Benefits and risks of hair, skin, and nail supplements in older adults

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This article reviews popular supplements that older adults, especially women, take to improve their hair, skin, and nails. While some supplements like nicotinamide show promise for sun-damaged skin, most lack strong evidence of benefit in healthy people. Important risks include biotin interfering with heart and thyroid tests, too much zinc causing copper deficiency, and excess vitamins A and E building up to toxic levels. Doctors should talk to older patients about these supplements and help them make informed decisions based on scientific evidence rather than marketing claims.

When Nature Meets Oncology: Unraveling Herb–Drug Interactions in Cancer Therapy

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Many cancer patients use herbal supplements and natural products alongside their cancer treatments without telling their doctors, which can be dangerous. Some natural products like St. John’s Wort and grapefruit juice significantly alter how the body processes cancer medications, potentially making treatments ineffective or toxic. The review provides guidance on which natural products are safe to use with cancer therapy and which should be avoided completely, emphasizing the importance of open communication between patients and healthcare providers.

Interactions between classic psychedelics and serotonergic antidepressants: Effects on the acute psychedelic subjective experience, well-being and depressive symptoms from a prospective survey study

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This study examines how antidepressant medications (like SSRIs) affect the experience of classic psychedelics such as psilocybin and LSD. Researchers found that people taking these antidepressants experienced less intense emotional and mystical effects from psychedelics, but surprisingly, both groups showed similar improvements in mood and well-being several weeks later. This raises important questions about whether patients need to stop their antidepressants before using psychedelics therapeutically.

Pharmacokinetics of Psilocybin: A Systematic Review

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This review examines how the body processes psilocybin, a compound from magic mushrooms being studied for treating depression and anxiety. When taken orally, psilocybin is quickly converted to its active form, psilocin, which reaches peak levels in the bloodstream within 1-4 hours and is eliminated mainly through urine. The body’s ability to process psilocybin involves specific liver enzymes that vary between individuals, potentially explaining why people respond differently to the same dose and why certain medications can interfere with its effects.

Evaluation of the combined efficacy of inhibitors of heat shock protein 90 and calcineurin with commonly used antifungals against Aspergillus, Rhizopus, and Fusarium isolates

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Scientists tested combinations of common antifungal medications with special inhibitor drugs that target fungal stress-response systems. When combined, these drugs worked better together against dangerous mold infections like Aspergillus and Rhizopus, especially those that are resistant to standard treatments. The combinations rarely caused harmful interactions and often enhanced the antifungal effects, suggesting this approach could improve treatment of serious mold infections.

Enhancing antifungal stewardship: The educational and healthcare benefits of involving pharmacy students in audits

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This study examined how pharmacy students could help improve the use of fluconazole, a common antifungal medication, in hospitals. Researchers found that nearly one-third of fluconazole prescriptions were not being used appropriately. By having pharmacy students participate in reviewing prescriptions under expert supervision, hospitals could better identify problems and educate future pharmacists, while the students gained valuable real-world experience in patient care.

Enhancing antifungal stewardship: The educational and healthcare benefits of involving pharmacy students in audits

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This study involved pharmacy students in reviewing fluconazole prescriptions at two Sydney hospitals to improve antifungal medication use. The researchers found that many fluconazole prescriptions were not being used appropriately, and some patients had dangerous drug interactions. The pharmacy students gained valuable real-world experience while helping the hospitals improve their antifungal stewardship practices.

Enhancing antifungal stewardship: The educational and healthcare benefits of involving pharmacy students in audits

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Researchers studied how involving pharmacy students in reviewing fluconazole (an antifungal medication) prescriptions could help hospitals improve their antifungal medication use and provide valuable training. Out of 145 prescriptions audited, about two-thirds were appropriate while one-third had issues like unnecessary use or drug interactions. Both the students and hospitals benefited significantly, with students gaining practical clinical experience while hospitals identified prescribing problems that could be improved.

Deep Fungal Infection of the Skin with Two Rare Fungi in a Dog Being Treated with Immunosuppressant Therapy: A Case Report

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An 8-year-old dog receiving long-term immunosuppressive medication for brain inflammation developed rare fungal skin infections caused by two unusual fungi not previously reported together in veterinary medicine. Diagnosis required multiple tests including tissue samples, staining techniques, and genetic testing. Despite treatment with antifungal medications and careful adjustment of immunosuppressive drugs, the infections did not improve, highlighting the difficult balance between fighting infections and controlling the underlying immune disease.

Research Keyword: drug interactions