Research Keyword: drug efflux pumps

Aspergillus fumigatus ctf1 – a novel zinc finger transcription factor involved in azole resistance

mycolabadmin

Researchers discovered that a gene called ctf1 in a harmful fungus called Aspergillus fumigatus helps control how resistant the fungus is to antifungal medications like voriconazole. When this gene is removed, the fungus becomes more resistant to these drugs because it pumps them out more efficiently. Understanding this mechanism could help doctors develop better treatments for serious fungal infections in vulnerable patients.

Read More »

Drug repurposing to fight resistant fungal species: Recent developments as novel therapeutic strategies

mycolabadmin

This editorial highlights the growing problem of fungal infections that resist current treatments, causing millions of deaths worldwide each year. Researchers are finding new ways to fight these resistant infections by repurposing existing drugs in new combinations and discovering novel compounds from natural sources. The collection of studies presented shows promising results using combinations like minocycline with antifungal drugs, natural compounds like baicalin, and AI technology to predict resistance patterns. These innovative approaches offer hope for better treatment options for patients suffering from serious fungal infections.

Read More »

Evaluation of Antifungal Activity Against Candida albicans Isolates From HIV-Positive Patients with Oral Candidiasis in a Major Referral Hospital, West Java, Indonesia

mycolabadmin

This study examined fungal infections in HIV-positive patients’ mouths at an Indonesian hospital. Researchers identified which Candida species caused the infections and tested how well common antifungal medications worked against them. They found that while a specific antifungal drug (fluconazole) was effective in most cases, some infections showed resistance, suggesting the need for careful monitoring and personalized treatment approaches.

Read More »
Scroll to Top