drug delivery – Page 2

Therapeutic Potential of Bioactive Compounds in Edible Mushroom-Derived Extracellular Vesicles: Isolation and Characterization of EVs from Pleurotus eryngii

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Scientists have isolated and studied tiny capsule-like particles called extracellular vesicles from the oyster mushroom Pleurotus eryngii. These vesicles, which are naturally produced by the mushroom, contain beneficial compounds like antioxidants that help protect cells from damage. The researchers found that vesicles from mushroom mycelium (the root-like part) were of higher quality and had stronger antioxidant effects than those from the fruiting body. These findings suggest that mushroom-derived vesicles could potentially be developed into health supplements or therapeutic treatments.

Research Progress of Polysaccharide-Gold Nanocomplexes in Drug Delivery

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Scientists are combining polysaccharides (natural compounds found in plants and organisms) with tiny gold particles to create better drug delivery systems. These hybrid nanoparticles can transport medicines directly to cancer cells while reducing side effects and improving treatment effectiveness. The review discusses how these gold-polysaccharide combinations can also fight bacteria and viruses, making them useful for various medical applications beyond cancer therapy.

Fungal and Microalgal Chitin: Structural Differences, Functional Properties, and Biomedical Applications

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Chitin is a natural fiber found in mushrooms, algae, and shellfish that has many medical and industrial uses. Traditional chitin from shellfish shells has environmental and contamination problems, so scientists are studying chitin from mushrooms and algae as cleaner alternatives. These sources produce chitin with different structures that can be better for certain medical applications, and can be extracted using environmentally friendly methods.

Fungal and Microalgal Chitin: Structural Differences, Functional Properties, and Biomedical Applications

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Chitin is a natural fiber found in mushroom cell walls and algae that can be extracted and used for medical applications like wound healing and drug delivery. Traditional chitin from shellfish shells contains heavy metals and requires harsh chemicals to extract, but chitin from mushrooms and algae is cleaner, more sustainable, and can be grown year-round. Scientists have developed environmentally friendly extraction methods using special solvents and enzymes that preserve the chitin’s useful properties. This makes fungal and algal chitin promising alternatives for creating biomedical materials and packaging.

Harnessing pycnidia-forming fungi for eco-friendly nanoparticle production, applications, and limitations

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Scientists are using special fungi called pycnidial fungi to create tiny nanoparticles that could revolutionize medicine and environmental cleanup. These fungi naturally produce chemicals that can turn metal into useful nanoparticles without the toxic processes used in factories. The resulting nanoparticles show promise in fighting bacteria, cancer cells, and cleaning polluted water, offering a safer and more eco-friendly alternative to traditional methods.

Conjugation of a Cryptococcus neoformans-derived metalloprotease to antifungal-loaded PLGA nanoparticles treats neural cryptococcosis in an in vitro model

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Researchers developed tiny nanoparticle carriers coated with a fungal enzyme that helps them cross the protective barrier around the brain. These particles were loaded with an antifungal drug to treat brain infections caused by Cryptococcus neoformans. In laboratory tests, the Mpr1-coated particles successfully penetrated the blood-brain barrier better than regular nanoparticles and were more effective at killing the fungal cells.

Strategies and materials for the prevention and treatment of biofilms

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Biofilms are sticky communities of bacteria that form on medical devices and surfaces, making infections very difficult to treat with antibiotics. This review explains how biofilms develop in stages and describes different ways to stop them from forming or to destroy them once they exist. Solutions include special coatings on medical implants, natural plant extracts like essential oils, and engineered proteins called antimicrobial peptides that fight bacteria without creating antibiotic resistance.

Encapsulation of progesterone in reishi mushroom composite for optimized hormone replacement and targeted anticancer therapy

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Researchers created a new treatment by combining progesterone (a hormone) with reishi mushroom powder to make it work better in the body. The mushroom acts like a protective wrapper that slowly releases the hormone, making it more effective for treating menopausal symptoms and fighting breast cancer cells. The combination also fights harmful bacteria and fungi while remaining stable during storage. This approach combines traditional medicine with modern pharmaceutical science.

Mitigation of radiation-induced esophageal fibrosis by macrophage-targeted phosphatidylserine-containing liposomes with partial PEGylation

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Radiation therapy used to treat esophageal cancer often causes scarring and tissue damage that makes swallowing difficult. Researchers developed special fatty particles called PEGylated phosphatidylserine-containing liposomes that can reduce this scarring by calming down immune cells called macrophages. In studies using animal models and laboratory tests, these particles successfully reduced fibrosis, preserved normal tissue structure, and promoted muscle healing, offering hope for better management of radiation therapy side effects.

Design and Evaluation of a Inonotus obliquus–AgNP–Maltodextrin Delivery System: Antioxidant, Antimicrobial, Acetylcholinesterase Inhibitory and Cytotoxic Potential

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Researchers studied Chaga mushroom from Romania and developed new ways to package and deliver its beneficial compounds using silver nanoparticles and a food-safe ingredient called maltodextrin. These new delivery systems were designed to work better in the body by improving how well the mushroom’s active ingredients dissolve and stay stable. Testing showed these enhanced formulations were very effective at fighting bacteria, protecting cells from damage, and killing cancer cells.

Research Keyword: drug delivery