drug delivery systems

Targeting Polycystic Ovary Syndrome (PCOS) Pathophysiology with Flavonoids: From Adipokine–Cytokine Crosstalk to Insulin Resistance and Reproductive Dysfunctions

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Polycystic ovary syndrome (PCOS) is a common hormonal disorder affecting millions of women that causes irregular periods, infertility, and metabolic problems. Flavonoids are beneficial plant compounds found in fruits, vegetables, and tea that show promise in treating PCOS by improving insulin sensitivity, reducing inflammation, and balancing hormones. While current medications have limited benefits and side effects, flavonoid supplements could offer a safer, natural way to address multiple PCOS problems simultaneously. However, more large-scale clinical studies are needed to confirm their effectiveness and establish optimal dosing.

Algal pigments: Therapeutic potential and food applications

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Colorful algae contain powerful natural compounds that can help treat serious health problems like cancer, diabetes, and obesity. Scientists are using special nano-technology to deliver these algal compounds more effectively in medicines. Algae-based pigments like chlorophyll and carotenoids are already used in supplements and healthy foods to boost overall wellness. These compounds also help maintain a healthy gut and reduce inflammation in the body.

Deciphering the formation of biogenic nanoparticles and their protein corona: State-of-the-art and analytical challenges

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Scientists have developed environmentally friendly methods to create tiny metal particles (nanoparticles) using living organisms like bacteria, fungi, and plants instead of toxic chemicals. These bioengineered nanoparticles are coated with natural biological molecules that make them safer and more stable. This review explains how these particles are made, what analytical tools scientists use to study them, and their potential uses in medicine, environmental cleanup, and agriculture.

Nanoencapsulation of Biotics: Feasibility to Enhance Stability and Delivery for Improved Gut Health

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This review explores how tiny nanoparticles can protect beneficial bacteria and dietary compounds as they travel through the digestive system. These nanotechnologies help probiotics survive stomach acid and reach the intestines where they provide health benefits. The research shows promising results for treating digestive diseases and improving overall gut health through better delivery of microbiota-modulating substances.

Experimental research on fungal inhibition using dissolving microneedles of terbinafine hydrochloride nanoemulsion for beta-1,3-glucanase

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Researchers developed a new patch treatment for nail fungus using tiny dissolving needles that deliver antifungal medication directly into the skin near infected nails. The patch combines two active ingredients that work together to kill fungus and break down protective biofilm layers that make fungal infections hard to treat. Testing showed the patch was safe, effective, and delivered much more medication to the infected area compared to traditional creams or pills.

Sodium Alginate Modifications: A Critical Review of Current Strategies and Emerging Applications

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Sodium alginate is a natural substance from seaweed that is safe to eat and widely used in foods, medicines, and environmental cleanup. Scientists have developed various ways to modify sodium alginate to make it stronger, more stable, and better at specific jobs like delivering medicines or creating edible packaging. This review explains both the gentle, food-safe ways to modify alginate for food products and stronger chemical methods used for medical and environmental applications. The modifications allow alginate to work better in areas like wound healing, removing pollutants from water, and protecting food freshness.

Harnessing pycnidia-forming fungi for eco-friendly nanoparticle production, applications, and limitations

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Certain fungi called pycnidial fungi can create tiny particles called nanoparticles that are useful in medicine, agriculture, and environmental cleanup. These fungi naturally produce chemicals and enzymes that reduce metal ions into nanoparticles, which have antimicrobial and cancer-fighting properties. While this biological approach is more environmentally friendly than chemical methods, scientists still need to solve challenges like making it work at large scales and ensuring the nanoparticles are safe and stable.

Fungus-targeted nanomicelles enable microRNA delivery for suppression of virulence in Aspergillus fumigatus as a novel antifungal approach

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Researchers developed a new way to fight dangerous fungal infections caused by Aspergillus fumigatus, which increasingly resists standard antifungal drugs. They used tiny molecules called microRNAs packaged in even tinier delivery vehicles to turn off genes that help the fungus survive. When these microRNAs were introduced, the fungus became much more vulnerable to the body’s immune system and to stress. This novel approach could eventually help treat infections that are otherwise difficult to cure.

Sustainable Extraction and Multimodal Characterization of Fungal Chitosan from Agaricus bisporus

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Researchers successfully extracted chitosan from button mushrooms (Agaricus bisporus) using environmentally friendly chemical processes. This fungal-derived chitosan offers a sustainable alternative to traditional sources from shellfish and avoids issues like allergies and harsh chemical pollution. The extracted material showed promising properties for medical applications including wound healing and drug delivery systems.

The In vitro Effect of Nanoliposomal Amphotericin B Against Rhizopus arrhizus Isolated From COVID-19-Associated Mucormycosis Patients

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Scientists tested a new nano-formulation of the antifungal drug amphotericin B against a dangerous fungus (Rhizopus arrhizus) that infected COVID-19 patients with mucormycosis. The nanoliposomal version of the drug worked much better than regular amphotericin B and other antifungal medications currently used, showing much lower concentrations needed to kill the fungus. This research suggests the new nano-formulation could be a more effective treatment option for patients with this serious COVID-19 related fungal infection.

Research Keyword: drug delivery systems