drug delivery – mycolab.ai

Overcoming Solubility Challenges: Micronization of Berberine Using the GAS Antisolvent Technique

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Berberine is a traditional medicinal compound that could treat many diseases but doesn’t work well in the body because it doesn’t dissolve in water. Researchers used a special technique with pressurized carbon dioxide to break berberine into much smaller particles. This made the particles dissolve 18% better in water, which could make berberine-based medicines more effective at treating diabetes, high cholesterol, and other conditions.

Synthesis of fungal polysaccharide-based nanoemulsions for cancer treatment

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Researchers developed tiny capsules (nanoemulsions) made from corn protein and chitosan to better deliver shiitake mushroom compounds to treat cancer and reduce inflammation. When shiitake extract was enclosed in these nano-sized carriers, it became much more effective at killing breast cancer cells, fighting bacteria, and reducing inflammation compared to using the mushroom extract alone. This technology could lead to new natural medicines and health supplements that are more effective at lower doses.

Poly(lactic Acid): A Versatile Biobased Polymer for the Future with Multifunctional Properties—From Monomer Synthesis, Polymerization Techniques and Molecular Weight Increase to PLA Applications

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PLA is an eco-friendly plastic made from renewable resources like corn and sugarcane that can break down naturally, making it a sustainable alternative to regular petroleum-based plastics. Scientists have developed various methods to manufacture PLA with different strengths and properties suitable for medical devices, packaging, and other applications. The review examines how different catalysts and manufacturing techniques affect the quality and durability of PLA products, and discusses its potential to help reduce plastic pollution.

Green Myco-Synthesis of Zinc Oxide Nanoparticles Using Cortinarius sp.: Hepatoprotective, Antimicrobial, and Antioxidant Potential for Biomedical Applications

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Researchers used mushroom extracts to create tiny zinc oxide particles in an environmentally friendly way. These nanoparticles were tested in mice with liver damage and showed significant protective effects. The particles also demonstrated strong abilities to fight bacteria and fungal infections while acting as powerful antioxidants, suggesting potential use in future medical treatments.

Processes of Obtaining Nanostructured Materials with a Hierarchical Porous Structure on the Example of Alginate Aerogels

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Scientists created lightweight, sponge-like materials called aerogels made from alginate (a substance derived from seaweed) with special internal structures. They tested three different techniques to create these structures: using soap-like surfactants, using a plant protein called zein, and using pressurized carbon dioxide. Each method produced materials with different pore sizes and characteristics, making them suitable for different medical applications like delivering medications slowly or growing cells for tissue repair.

Innovative Bioactive Nanofibrous Materials Combining Medicinal and Aromatic Plant Extracts and Electrospinning Method

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This research explains how scientists use a technique called electrospinning to create tiny, beneficial fibers from medicinal plants. By combining plant extracts like turmeric with biodegradable polymers, researchers create advanced materials that can deliver medicine, promote wound healing, and fight bacteria. These innovative fibers represent a natural approach to healthcare, bringing ancient plant wisdom into modern nanotechnology for practical medical applications.

Biomimetic Nanotechnology Vol. 3

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Scientists are developing new technologies inspired by nature at extremely small scales to solve real-world problems. This collection showcases five innovative studies using mushrooms and plants to create nanoparticles, developing new treatments for heart disease, and creating smart materials that can detect harmful chemicals. These nature-inspired approaches are often safer, more sustainable, and more effective than traditional methods.

Antifungal Efficacy of Luliconazole-Loaded Nanostructured Lipid-Carrier Gel in an Animal Model of Dermatophytosis

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Researchers developed a new antifungal gel containing luliconazole loaded into tiny lipid nanoparticles to treat stubborn fungal skin infections caused by Trichophyton indotineae that resist standard terbinafine treatment. Testing in guinea pigs showed this new nanoformulation penetrated skin better and cleared infections faster (21 days) compared to regular luliconazole gel (28 days) and terbinafine-treated animals. The nanoparticle delivery system improved the drug’s ability to reach infected skin layers and showed no harmful side effects, offering promise for treating resistant fungal infections in patients.

Fungus-targeted nanomicelles enable microRNA delivery for suppression of virulence in Aspergillus fumigatus as a novel antifungal approach

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Researchers developed a new way to fight dangerous fungal infections caused by Aspergillus fumigatus by using tiny particles called nanomicelles to deliver genetic material (microRNAs) directly into fungal cells. These microRNAs target and reduce the production of melanin, a protective pigment that helps the fungus resist immune attacks. By weakening this defense, the fungal cells become more vulnerable to the body’s immune system and to stress, offering a novel approach to treat serious fungal infections that have become resistant to standard antifungal drugs.

Harnessing pycnidia-forming fungi for eco-friendly nanoparticle production, applications, and limitations

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Certain types of fungi can produce tiny metal particles called nanoparticles that have useful properties. These fungi-made nanoparticles can kill bacteria, fight cancer cells, clean pollutants from water and soil, and be used in medicines and agriculture. Unlike traditional chemical methods for making nanoparticles, using fungi is cleaner and safer for the environment, though scientists still need to understand more about how they work and ensure they are safe to use widely.

Research Keyword: drug delivery