Research Keyword: Drug combination

HIV protease inhibitors restore amphotericin B activity against Candida

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Researchers discovered that HIV protease inhibitors, medications commonly used to treat HIV, can significantly enhance the effectiveness of amphotericin B, a powerful antifungal drug. When combined, these medications work synergistically to kill the dangerous fungus Candida auris, reduce its ability to form protective biofilms, and lower infection levels. This finding suggests a promising new treatment strategy for multidrug-resistant fungal infections that currently pose a serious global health threat.

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Characterizing antimicrobial activity of environmental Streptomyces spp. and oral bacterial and fungal isolates from Canis familiaris and Felis catus

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Researchers collected bacteria and fungi from the mouths of pet dogs and cats, as well as environmental soil bacteria, to search for natural antimicrobial compounds. They found that some of these microorganisms produce substances that can kill harmful bacteria like E. coli and fungi like Candida albicans, especially when combined with existing antifungal medications. Notably, one environmental bacterium (Streptomyces) produced a compound that was even effective against fungal strains resistant to common antifungal drugs, suggesting promising new treatment possibilities.

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Vesicle inhibition reduces Candida biofilm resistance

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Researchers found that common FDA-approved drugs designed to block vesicle production in human cells can also reduce the protective matrix that Candida fungus builds around itself in biofilms. By combining these vesicle-blocking drugs with the antifungal fluconazole, the scientists were able to kill biofilm-forming Candida more effectively than either treatment alone. This discovery suggests a new approach to treating stubborn fungal infections on medical devices like catheters, potentially eliminating the need to surgically remove infected equipment.

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