Research Keyword: double-hit mechanism

Pore-Forming Cardiotoxin VVA2 (Volvatoxin A2) Variant I82E/L86K Is an Atypical Duplex-Specific Nuclease

Researchers discovered that a toxic protein from edible mushrooms called VVA2 has a hidden ability to cut double-stranded DNA. When modified to remove its toxic effects, this protein became a powerful DNA-cutting enzyme that works best at warm temperatures and requires specific metal ions to function. This discovery could have practical applications in DNA research and diagnostic testing.

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