Research Keyword: DNA methylation

Identification of Blood Biomarkers of Psilocybin-Assisted Therapy Treatment Response for Generalised Anxiety Disorder

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Researchers studied how psilocybin-assisted therapy works for people with anxiety disorders by examining blood samples from patients who responded well to treatment versus those who didn’t. They identified four genes whose expression patterns could help predict which anxiety patients would benefit from psilocybin therapy before starting treatment. This breakthrough could help doctors avoid giving intensive treatment to patients unlikely to respond and instead direct them toward more effective alternatives.

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Molecular mechanisms of metal toxicity and transcriptional/post-transcriptional regulation in plant model systems

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Plants face serious damage from heavy metals like cadmium, arsenic, and chromium in contaminated soils and water. Scientists are discovering how plants defend themselves through changes in gene expression, special proteins that trap metals, and modifications to their DNA that control stress response genes. Understanding these natural defense mechanisms could help us develop crops that survive in polluted environments and remove heavy metals from contaminated areas, making food safer and protecting human health.

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Adaptive Changes and Genetic Mechanisms in Organisms Under Controlled Conditions: A Review

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Organisms adapt to their environments through changes in their genes and how genes are expressed, processes that can happen over many generations even in laboratory settings. Scientists study these adaptations in fungi, insects, and plants grown under controlled conditions to understand how evolution works over shorter timeframes. The research shows that both genetic mutations and modifications to how genes work (without changing DNA itself) drive these adaptive changes. Understanding these mechanisms helps scientists improve crop productivity, develop disease resistance, and address environmental challenges like climate change.

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Comprehensive analysis of the mechanisms conferring resistance to phenamacril in the Fusarium species

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Fusarium fungi cause serious diseases in crops like wheat, rice, and vegetables worldwide, leading to significant food losses and contamination with harmful toxins. Phenamacril is a modern fungicide designed to fight these fungi by targeting a specific protein called myosin-5. However, the fungi have developed resistance to this fungicide through genetic changes and other mechanisms, making it less effective over time. Farmers need to use multiple strategies including crop rotation and resistant plant varieties rather than relying only on fungicides to successfully manage these diseases.

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Epigenome-wide association study of BMI and waist-to-hip ratio and their associations with dietary patterns in Korean adults

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This research examined how different types of obesity (overall body weight versus belly fat) are associated with changes in DNA methylation patterns in Korean adults. The study found that certain DNA regions become less methylated in obese individuals, and that these epigenetic changes are linked to different dietary patterns. The findings suggest that specific foods may influence these epigenetic modifications differently depending on whether someone has overall obesity or more belly fat, opening new possibilities for using diet to prevent or manage obesity.

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Genetic differentiation in the MAT-proximal region is not sufficient for suppressing recombination in Podospora anserina

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Scientists studied why certain regions of fungal chromosomes don’t allow genetic recombination like normal chromosomes do. By creating a mutant fungus where a previously different genetic region became identical, they found that genetic differences alone don’t explain why recombination stops. Instead, they discovered that other biological mechanisms, possibly involving chemical modifications to DNA or special regulatory proteins, must be responsible for preventing genetic mixing in these special chromosome regions.

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Comprehensive analysis of the mechanisms conferring resistance to phenamacril in the Fusarium species

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Fusarium fungi cause serious diseases in crops like wheat, corn, and fruits, causing huge losses in agriculture worldwide. Phenamacril is a new antifungal drug designed specifically to fight these fungi by blocking a protein they need to grow. However, the fungi are developing resistance to this drug through genetic mutations and other biological mechanisms, making it less effective over time. Understanding how this resistance develops helps scientists develop better strategies to maintain the drug’s effectiveness and protect our food supply.

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