diabetes mellitus – mycolab.ai

Seagrass Enhalus acoroides extract mitigates obesity and diabetes via GLP-1, PPARγ, SREBP-1c modulation and gut microbiome restoration in diabetic zebrafish

mycolabadmin

Researchers tested a seagrass extract called Enhalus acoroides on diabetic zebrafish and found it effectively reduced body weight and blood sugar levels, performing as well or better than metformin, a common diabetes medication. The extract worked by activating genes that promote glucose metabolism and reducing genes that promote fat storage. Importantly, the extract also restored healthy gut bacteria balance, which appears to play a key role in its therapeutic effects. These findings suggest that seagrass could be developed into a natural supplement or functional food to help treat obesity and diabetes.

Recognizing the Importance of Public Health Mycology

mycolabadmin

Fungal infections are becoming a major global health problem, causing millions of cases and deaths each year, especially in people with weakened immune systems. Different types of fungal infections like aspergillosis and candidiasis are becoming harder to treat because fungi are developing resistance to antifungal medications. The editorial emphasizes that better diagnosis, treatment access, and disease tracking are needed worldwide to combat this growing threat.

Epidemiology and outcomes of Candida-associated osteoarticular infections: A multicentre retrospective study from Turkey

mycolabadmin

This study examined 73 patients in Turkey who developed bone and joint infections caused by Candida fungi over ten years. The researchers found that diabetes was very common among patients and made recovery harder, while surgery to clean out infected tissue significantly improved outcomes. Importantly, they discovered resistance to common antifungal medications was higher in certain Candida species compared to others.

Pulmonary Mucormycosis in Diabetic Patients: A Case Series From a Tertiary Respiratory Center in Sri Lanka

mycolabadmin

This case study describes three diabetic patients in Sri Lanka who developed a serious lung infection caused by a fungus called mucormycosis. The infection caused cavities in the lungs and symptoms like fever, cough, and weight loss. Two patients recovered with antifungal medication (amphotericin B) and surgery, while one patient sadly died despite receiving treatment. The study emphasizes that doctors should consider this infection in diabetic patients with unusual lung symptoms to catch it early.

Epidemiology of mucormycosis in COVID-19 patients in northwest Iran: Rhizopus arrhizus as the predominant species

mycolabadmin

During the COVID-19 pandemic, a dangerous fungal infection called mucormycosis was found in 63 patients in northwestern Iran. The infection was caused mainly by a fungus called Rhizopus arrhizus and most commonly affected the sinuses and brain. Most patients had been given high-dose steroids to treat their COVID-19, which weakened their immune systems and increased their risk of this serious fungal infection, especially those with diabetes.

Pulmonary Mucormycosis in Diabetic Patients: A Case Series From a Tertiary Respiratory Center in Sri Lanka

mycolabadmin

This case study describes three patients with diabetes who developed a serious lung infection caused by a rare fungus called mucormycosis. The infection presented with various symptoms like cough, fever, and weight loss, and was diagnosed using lung tissue samples that showed the characteristic fungal structures. Two patients recovered with prolonged antifungal medication treatment, while one patient unfortunately died despite receiving prompt treatment, highlighting how serious this infection can be.

Impact of glycemic control on coccidioidomycosis outcomes in patients with underlying diabetes mellitus in central California

mycolabadmin

This study examined how blood sugar control affects outcomes in patients with both diabetes and coccidioidomycosis, a fungal infection common in central California. Researchers found that patients with poorly controlled diabetes (higher HbA1c levels) had higher rates of serious lung disease with cavities and were less likely to recover from the infection. The study highlights that managing blood sugar levels may be just as important as taking antifungal medications when treating this dual condition.

Epidemiology of mucormycosis in COVID-19 patients in northwest Iran: Rhizopus arrhizus as the predominant species

mycolabadmin

During the COVID-19 pandemic, some patients developed a severe fungal infection called mucormycosis alongside their coronavirus infection. This study found that 63 COVID-19 patients in Iran developed mucormycosis, which primarily affected the sinuses and brain. The researchers identified that a fungus called Rhizopus arrhizus caused most infections, and patients who received corticosteroids (used to treat severe COVID-19) had a higher risk, especially those who developed diabetes from the steroids.

Brazilian task force for the management of mucormycosis

mycolabadmin

Mucormycosis is a rare but deadly fungal infection that has been increasingly reported in Brazil, especially during the COVID-19 pandemic. This Brazilian medical task force developed practical guidelines for diagnosing and treating this serious infection, which primarily affects people with uncontrolled diabetes or weakened immune systems. The key to survival is early diagnosis combined with aggressive surgery and specific antifungal medications, along with controlling blood sugar and immune system suppression.

Simplicillium sinense sp. nov., a novel potential pathogen of tinea faciei

mycolabadmin

Researchers identified a new fungal species called Simplicillium sinense that caused a facial skin infection (tinea faciei) in a 46-year-old man with diabetes. The fungus was resistant to most common antifungal medications but responded well to terbinafine treatment. This is the first reported case of a Simplicillium infection causing facial ringworm, expanding our understanding of rare fungal pathogens.

Research Keyword: diabetes mellitus