developmental neurotoxicity

Psilocybin During the Postpartum Period Induces Long-Lasting Adverse Effects in Both Mothers and Offspring

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A new study shows that psilocybin, a psychedelic compound being tested for postpartum depression, may actually cause harm during the breastfeeding period. While the drug helped non-pregnant mice feel less anxious, it made postpartum mothers more anxious and worsened their caregiving behaviors. Even more concerning, baby mice exposed to psilocybin through breast milk developed mood and social problems as adults, suggesting potential lasting risks for human infants.

Psilocybin during the postpartum period induces long-lasting adverse effects in both mothers and offspring

mycolabadmin

Researchers tested whether psilocybin could help postpartum depression in mice, but found it actually made things worse for both mothers and their babies. While psilocybin normally reduces depression and anxiety, it had the opposite effect during the postpartum period, making mothers more anxious and disrupting their care of pups. Babies exposed to psilocybin through breastfeeding or direct exposure developed anhedonia (inability to feel pleasure) as adults. These findings suggest that the postpartum period may be a particularly vulnerable time for psychedelic use, and more research is needed before considering these drugs for postpartum depression treatment.