dermatophytosis – mycolab.ai

Dermatophytosis in a Chilean fox: first case of Nannizzia gypsea in Lycalopex griseus and the need for a one health approach

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A young wild Chilean fox was found with a skin infection caused by a fungus called Nannizzia gypsea, which lives in soil and can infect animals and humans. This is the first time this fungus has been documented in foxes anywhere. Doctors treated the fox with an antifungal cream and it recovered completely. The case highlights how increasing urbanization and contact between domestic pets, wild animals, and humans can spread fungal diseases, emphasizing the need for a coordinated public health approach.

Severe tinea faciei mimicking favus-like lesions linked to rabbit exposure: A case report

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A young girl developed facial rashes after getting a pet rabbit and was initially treated for eczema, but her condition worsened. Tests revealed she and her rabbit both had a fungal infection caused by Trichophyton mentagrophytes. The infection was successfully treated with oral antifungal medication. This case highlights how pet contact can transmit fungal infections to children and the importance of proper diagnosis before starting treatment.

Antifungal Efficacy of Luliconazole-Loaded Nanostructured Lipid-Carrier Gel in an Animal Model of Dermatophytosis

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Researchers developed a new antifungal gel containing luliconazole loaded into tiny lipid nanoparticles to treat stubborn fungal skin infections caused by Trichophyton indotineae that resist standard terbinafine treatment. Testing in guinea pigs showed this new nanoformulation penetrated skin better and cleared infections faster (21 days) compared to regular luliconazole gel (28 days) and terbinafine-treated animals. The nanoparticle delivery system improved the drug’s ability to reach infected skin layers and showed no harmful side effects, offering promise for treating resistant fungal infections in patients.

SUB6 Subtilisin is Involved During the Initial Adhesion of Trichophyton benhamiae and T. mentagrophytes onto Reconstructed Human Epidermis

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Researchers studied a fungal protease called SUB6 produced by common skin infection-causing fungi. Using engineered fungi lacking this protein, they found that SUB6 helps fungi initially stick to skin but isn’t absolutely required for infection. The fungi can compensate by producing other proteases, suggesting SUB6 might be better used as a diagnostic marker to detect fungal infections rather than as a drug target.

Dermatophytosis in a Chilean fox: first case of Nannizzia gypsea in Lycalopex griseus and the need for a one health approach

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A wild South American grey fox found near Santiago, Chile was treated for a skin infection caused by a fungus called Nannizzia gypsea. This is the first time this particular fungus has been documented in foxes, raising concerns about how increasing contact between domestic animals, wildlife, and humans due to urbanization may spread fungal diseases. The fox was successfully treated with topical antifungal cream, and the fungus was found to be susceptible to all tested antifungal medications.

Wildlife Dermatophytoses in Central Italy (Umbria and Marche Regions): A Fifteen-Year Investigation (2010–2024)

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Researchers in central Italy studied fungal skin infections in wild animals over 15 years to understand disease patterns and public health risks. They found that about 11% of wild animals tested positive for dermatophytes (skin fungi), with some species dangerous to humans. The most common fungi found were Paraphyton mirabile and Trichophyton mentagrophytes, which can spread to people through contact with infected animals. The study highlights the importance of monitoring wildlife health and using protective equipment when handling wild animals.

First reported Canadian case of Trichophyton mentagrophytes genotype VII infection among men who have sex with men (MSM)

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A Canadian man contracted a rare fungal skin infection caused by Trichophyton mentagrophytes genotype VII during a trip to Mexico, likely through sexual contact. The infection presented as deep, painful lesions in the genital area that didn’t respond to typical treatments and required 10 weeks of oral and topical antifungal medication to cure. This is the first confirmed case in Canada and highlights the importance of doctors being aware of sexually transmitted fungal infections, especially in patients with unusual rashes that don’t improve with standard treatments.

Surgical management of deep dermatophytosis in a patient with CARD9 deficiency

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A 23-year-old man from North Africa with a genetic immune disorder (CARD9 deficiency) developed a serious fungal skin infection with deep tissue involvement. The infection caused multiple pus-filled pockets and hair loss on his scalp. Doctors treated him with both antifungal medications and surgery to drain the infected areas, resulting in complete healing after two weeks.

Superficial Fungal Infections in Children—What Do We Know?

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Superficial fungal infections like ringworm and athlete’s foot are common in children and are caused by fungi, yeasts, or molds that spread through contact with infected people, animals, or contaminated surfaces. These infections primarily affect the scalp, skin, and nails, with scalp infections being most common in young children. Treatment typically uses topical creams for mild cases or oral medications for more severe infections, particularly those affecting nails or the scalp. Proper hygiene, avoiding contaminated areas, and limiting contact with infected individuals or animals are key to prevention.

Recalcitrant dermatophytosis due to Trichophyton indotineae: A case series from Sarawak, Malaysia

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Three patients in Malaysia had persistent skin fungal infections caused by Trichophyton indotineae that did not respond to standard antifungal treatments. Genetic testing revealed these fungal strains carried a specific mutation making them resistant to terbinafine, the typical first-line treatment. While azole-based antifungals showed variable effectiveness depending on the specific drug and dose used, one patient achieved complete cure with voriconazole therapy. The study highlights the growing problem of drug-resistant fungal infections and the importance of targeted treatment based on laboratory testing.

Research Keyword: dermatophytosis