dereplication – mycolab.ai

Fungi: Pioneers of chemical creativity – Techniques and strategies to uncover fungal chemistry

mycolabadmin

This review explores how fungi produce remarkable chemical compounds that have been transformed into important medicines for over a century. Starting with penicillin in the 1940s, scientists have discovered dozens of fungal-derived drugs used to treat infections, prevent organ rejection, lower cholesterol, and fight cancer. Modern technology now allows researchers to discover and analyze these compounds much faster and with smaller samples than ever before.

Miniaturized high-throughput conversion of fungal strain collections into chemically characterized extract libraries for antimicrobial discovery

mycolabadmin

Scientists developed a fast, automated method called FLECS-96 to screen hundreds of fungal species for antimicrobial compounds in a small 96-well plate format. The method combines fungal culture, chemical extraction, and analysis to identify promising candidates against resistant bacteria like Staphylococcus aureus. The team successfully identified two bioactive compounds from the fungi tested. This innovation could significantly speed up the discovery of new antibiotics to combat antibiotic-resistant infections.

Marine-derived Acremonium strain prioritization using untargeted metabolomics approach for the identification of cytotoxic cyclic depsipeptides

mycolabadmin

Researchers discovered five potent anti-cancer compounds from Arctic fungi called Acremonium strains. Using advanced chemical analysis techniques, they identified and tested these cyclic depsipeptides against various cancer cell types. The most active compound showed promising results against breast cancer and melanoma cells with extremely low concentrations needed for effect. These findings suggest Arctic microorganisms could be valuable sources for developing new cancer treatments.

Research Keyword: dereplication

Fungi: Pioneers of chemical creativity – Techniques and strategies to uncover fungal chemistry

Miniaturized high-throughput conversion of fungal strain collections into chemically characterized extract libraries for antimicrobial discovery

Marine-derived Acremonium strain prioritization using untargeted metabolomics approach for the identification of cytotoxic cyclic depsipeptides