Research Keyword: Density functional theory

Vinigrol Tricyclic Scaffold Biosynthesis Employs an Atypical Terpene Cyclase and a Multipotent Cyclization Cascade

Scientists have discovered how a fungus produces vinigrol, a complex molecule with potential health benefits including lowering blood pressure and reducing inflammation. Using advanced computational tools and genetic engineering, researchers identified the specific genes and enzymes the fungus uses to build this molecule’s intricate three-ring structure. By modifying a key enzyme, they were able to create an entirely new diterpene molecule that doesn’t exist in nature, demonstrating the potential to engineer biological systems to produce novel medicinal compounds.

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Biomass carbon mining to develop nature-inspired materials for a circular economy

This paper explains how we can turn waste biomass from agriculture and industry into valuable materials to replace petroleum-based products. By using computational methods and artificial intelligence, researchers can design more efficient processes to convert plant and animal waste into bioplastics, chemicals, and building materials. Over 100 companies are already successfully doing this, creating products from waste coffee grounds, seaweed, agricultural residue, and other biomass sources.

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