Research Keyword: cytokine release

Medicinal Mushrooms: Bioactive Compounds, Use, and Clinical Trials

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This comprehensive review examines how medicinal mushrooms contain natural compounds that can boost immune function, fight cancer cells, reduce inflammation, and protect nerve cells. Different mushroom species like reishi, shiitake, and maitake contain various active substances such as beta-glucans and triterpenes that work through multiple biological pathways. While laboratory and animal studies show promising results, more human clinical trials are needed to confirm effectiveness and establish safe dosing guidelines.

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Classic psychedelics do not affect T cell and monocyte immune responses

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Researchers tested whether common psychedelic drugs (LSD, psilocin, DMT, and mescaline) directly affect human immune cells in laboratory conditions. They found that these psychedelics did not suppress T cell function or immune signaling at the doses tested. This is good news for patients with serious illnesses who might benefit from psychedelic-assisted therapy, as it suggests these treatments won’t dangerously weaken their already compromised immune systems.

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Sporoderm-removed ganoderma lucidum spore powder (S-GLSP) alleviates neuroinflammation injury by regulating microglial polarization through inhibition of NLRP3 inflammasome activation

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Researchers found that sporoderm-removed Ganoderma lucidum spore powder (S-GLSP) protects against Alzheimer’s disease by reducing brain inflammation. The supplement works by shifting immune cells in the brain called microglia from a harmful pro-inflammatory state to a protective anti-inflammatory state. This is accomplished by blocking the NLRP3 inflammasome, a key trigger of brain inflammation. In animal and cell studies, S-GLSP improved memory, reduced neuronal damage, and decreased harmful tau protein accumulation.

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A 3D Fusarium keratitis model reveals isolate-specific adhesion and invasion properties in the Fusarium solani species complex

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Researchers studied three species of Fusarium fungus that cause serious eye infections. They found that one species (F. keratoplasticum) is much more dangerous than the others, invading deeper into the eye and causing more damage. Using a new 3D model that mimics the structure of the human cornea, they discovered that Fusarium fungi penetrate much deeper than other fungal pathogens, which helps explain why eye infections from these fungi are so difficult to treat and why patients often lose their vision.

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