Research Keyword: culture degeneration

Comparative transcriptomics and metabolomics provide insight into degeneration-related physiological mechanisms of Morchella importuna after long-term preservation

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This research studied how to best preserve morel mushroom cultures for long periods without them losing quality. Scientists compared five different storage methods over 7 years and found that storing cultures in nutrient-poor conditions without repeatedly replicating them produced the healthiest mushrooms. The study identified specific genes and metabolic processes that stayed healthy under the best preservation method, offering farmers better ways to maintain morel quality for cultivation.

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Aspergillus terreus sectorization: a morphological phenomenon shedding light on amphotericin B resistance mechanism

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This study investigated why some strains of the fungus Aspergillus terreus are resistant to amphotericin B, an important antifungal medicine. Researchers compared a resistant strain with a mutated version that became susceptible to the drug. They found that certain genes called P-type ATPases are more active in resistant strains and may help the fungus pump ions and alter its cell membrane to survive the drug. Additionally, mutations in genes responsible for producing secondary metabolites were linked to the visible changes seen when fungal cultures degenerate.

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Aspergillus terreus sectorization: a morphological phenomenon shedding light on amphotericin B resistance mechanism

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When Aspergillus terreus fungi are grown in laboratory conditions for extended periods, they sometimes undergo changes that make them look different and behave differently. Scientists found that these changed strains become more susceptible to amphotericin B, a common antifungal drug. By studying the genes and proteins in both the original and changed strains, researchers discovered that special proteins called P-type ATPases appear to be responsible for the fungus’s natural resistance to this drug, offering new targets for developing better antifungal treatments.

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