Research Keyword: Cryptococcus

What Do We Know About Cryptococcus spp. in Portugal? One Health Systematic Review in a Comprehensive 13-Year Retrospective Study (2013–2025)

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This study examines cryptococcosis, a fungal infection that affects both animals and humans, across Portugal from 2013-2025. Researchers found that about 4.5% of animal samples tested positive for Cryptococcus species, with infections most common in dogs and cats. The infections peaked during summer months and were most prevalent in central Portugal, with different fungal species affecting different animal types. The research emphasizes the importance of coordinated monitoring across animals, humans, and the environment to better understand and control this disease.

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John Perfect Shares Insights on Infectious Diseases, Antifungal Therapy, and Drug Resistance

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Dr. John Perfect shares decades of experience treating fungal infections and developing antifungal medications. He discusses how treatments have evolved from highly toxic drugs to more effective options, but notes that fungal infections remain challenging, especially when patients develop resistance or have serious underlying diseases. He emphasizes the importance of combining drugs with immune therapies and shorter, more potent treatments rather than lengthy medication courses. Despite challenges, Dr. Perfect is optimistic about the future of medicine and encourages young scientists to pursue careers in this field.

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Isolation and Identification of Chemical Compounds from Agaricus blazei Murrill and Their In Vitro Antifungal Activities

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Researchers extracted and identified six chemical compounds from A. blazei mushrooms and tested their ability to fight fungal infections. The compounds showed promising activity against common fungal pathogens that cause infections in humans. This research suggests that A. blazei could be developed into natural antifungal treatments. The findings add to growing evidence that medicinal mushrooms contain valuable bioactive compounds with therapeutic potential.

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Fungi under fire: diagnostic capacities and antifungal availability in Peruvian healthcare facilities

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This study examined how well Peruvian hospitals can diagnose and treat serious fungal infections across the country. Researchers surveyed 54 healthcare centers and found that while basic fungal tests are available everywhere, advanced diagnostic tools and certain antifungal medications are mostly limited to the capital city of Lima. The research identifies major gaps in care that need to be addressed to help more patients survive these serious infections.

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Primary cutaneous mixed infection with Cryptococcus uniguttulatus and Mycobacterium tuberculosis

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A 43-year-old man had a persistent facial rash that didn’t improve with standard antifungal treatments. Doctors initially found a fungal infection called Cryptococcus uniguttulatus using culture tests. However, advanced molecular testing (DNA sequencing) revealed he also had a tuberculosis infection in the same skin lesion. Once both infections were treated with appropriate medications, the patient’s rash finally improved. This case shows that sometimes people can have multiple infections at the same location and that newer diagnostic methods are important for finding these hidden infections.

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