Research Keyword: CRISPR-Cas9

Microbe Profile: Streptomyces formicae KY5: an ANT-ibiotic factory

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Scientists discovered a special bacterium called Streptomyces formicae living in ant nests in Africa that produces powerful antibiotics effective against dangerous drug-resistant bacteria and fungi. This bacterium has the genetic potential to make at least 45 different antimicrobial compounds, though most are not currently being produced under standard laboratory conditions. Using advanced gene-editing techniques like CRISPR, researchers are working to activate these hidden pathways to discover new medicines. This research demonstrates how exploring bacteria in nature can lead to finding new antibiotics to treat serious infections.

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The Zn(II)2-Cys6-type zinc finger protein AoKap7 is involved in the growth, oxidative stress and kojic acid synthesis in Aspergillus oryzae

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Researchers studied a protein called AoKap7 in a fungus used to produce kojic acid, which is found in many cosmetic and food products. By deleting this protein gene, they found that fungi grew faster but produced much less kojic acid and were more sensitive to stress. The protein works as a master switch that controls both how fast the fungus grows and how much of the valuable kojic acid it makes.

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The antifungal mechanism of EntV-derived peptides is associated with a reduction in extracellular vesicle release

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Researchers discovered that a small peptide derived from a bacterium called EntV can fight Candida fungal infections by targeting specialized vesicles (tiny sacs) that fungi use to spread infections. Unlike traditional antifungal drugs that kill fungi, EntV works by blocking the release of these vesicles, reducing the fungus’s ability to infect and form protective biofilms. This new approach could lead to treatments that work against drug-resistant fungi without the toxicity issues of current antifungals.

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