Research Keyword: COVID-19

The first report of rhinosinusitis by Rhizopus delemar in a patient with severe COVID-19 in Iran: a case report

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A 63-year-old man hospitalized with COVID-19 developed a serious fungal sinus infection caused by a rare mold called Rhizopus delemar. Despite surgery to remove infected tissue and treatment with antifungal medication amphotericin B, the infection spread and the patient died after five weeks. This was the first documented case of this particular mold causing sinus infection in a COVID-19 patient in Iran, highlighting how severe fungal infections can occur as dangerous complications of COVID-19.

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A concise review of mushrooms antiviral and immunomodulatory properties that may combat against COVID-19

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This review explores how medicinal mushrooms have compounds that could help fight COVID-19 and boost immune function. Various mushroom species contain natural substances like beta-glucans and polysaccharides that have shown antiviral properties and can strengthen the body’s immune response. The research suggests these mushrooms could potentially be used alongside conventional treatments to help patients recover from COVID-19 more effectively.

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Quest for Anti-SARS-CoV-2 antiviral therapeutics: in-silico and in-vitro analysis of edible mushroom- Cordyceps militaris

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Researchers tested an edible mushroom called Cordyceps militaris to see if it could fight SARS-CoV-2, the virus that causes COVID-19. Using computer modeling and laboratory experiments, they found that a compound in the mushroom called cordycepin strongly attached to the virus’s spike protein and reduced viral numbers by about 50% in cell cultures. The study supports traditional uses of this mushroom and suggests it could be helpful in managing COVID-19 as the disease becomes endemic.

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One for All and All for One: Multikingdom Interplay in Severe Viral Pneumonia

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This editorial discusses how bacteria, viruses, and fungi interact in the lungs during severe pneumonia from COVID-19 or influenza. When mechanically ventilated patients with COVID-19 had bacterial infections detected, their immune systems released more inflammatory chemicals. However, the same pattern was not observed in influenza patients. Understanding how all these microorganisms work together may help doctors better treat these serious lung infections.

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Acute Respiratory Distress Syndrome Due to COVID-19-Associated Pulmonary Aspergillosis with Rare Extensive Tracheobronchial Pseudomembranous Involvement: A Case Report

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An elderly COVID-19 patient developed a rare and severe fungal infection caused by Aspergillus fungus in the airways, creating yellowish-white membrane-like deposits that blocked breathing. Despite identification of the fungus through examination and modern genetic testing, and treatment with antifungal medications, the patient’s condition worsened rapidly leading to organ failure and death. This case highlights how fungal infections can complicate COVID-19, especially in elderly patients on multiple medications, and stresses the importance of early recognition and immediate antifungal treatment.

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