Research Keyword: COVID-19 co-infection

Epidemiology of mucormycosis in COVID-19 patients in northwest Iran: Rhizopus arrhizus as the predominant species

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During the COVID-19 pandemic, a dangerous fungal infection called mucormycosis was found in 63 patients in northwestern Iran. The infection was caused mainly by a fungus called Rhizopus arrhizus and most commonly affected the sinuses and brain. Most patients had been given high-dose steroids to treat their COVID-19, which weakened their immune systems and increased their risk of this serious fungal infection, especially those with diabetes.

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Acute Respiratory Distress Syndrome Due to COVID-19-Associated Pulmonary Aspergillosis with Rare Extensive Tracheobronchial Pseudomembranous Involvement: A Case Report

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An 87-year-old man with COVID-19 developed a rare and severe fungal infection in his airways caused by Aspergillus fumigatus. Doctors used a camera tube (bronchoscope) to see thick, yellowish-white membrane-like material coating his entire windpipe and airways, which is an extremely rare complication. Despite starting antifungal medications, his condition rapidly worsened leading to organ failure and death. This case highlights how COVID-19 can leave patients vulnerable to serious secondary fungal infections that require immediate recognition and treatment.

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Invasive Fusarium rhinosinusitis in COVID-19 patients: report of three cases with successful management

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This study reports three cases of rare fungal sinus infections caused by Fusarium species that developed in COVID-19 patients. All three patients were successfully treated with a combination of surgical removal of infected tissue and antifungal medications. The cases highlight how COVID-19 and the use of steroids to treat it can increase the risk of serious fungal infections, emphasizing the importance of early detection and prompt treatment.

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Virulence factors of Candida spp. isolated from COVID-19 patients: hydrolytic enzyme activity and biofilm formation

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During the COVID-19 pandemic, many hospitalized patients developed fungal infections caused by Candida yeasts alongside their coronavirus infection. Researchers studied 71 Candida samples from COVID-19 patients to understand how these fungi cause disease by examining three damaging enzymes they produce and their ability to form protective biofilm layers. The findings showed that these fungi are highly virulent, producing strong enzyme activity that helps them invade tissues and resist treatment, which helps explain why these infections are particularly dangerous in COVID-19 patients.

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