Research Keyword: complement system

Microdosing Psychedelics to Restore Synaptic Density in Schizophrenia

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Schizophrenia involves excessive loss of connections between brain cells in areas responsible for emotion and thinking, leading to negative symptoms and cognitive problems. Research shows that small doses of psychedelics like psilocybin can promote the growth of new brain connections and reduce inflammation. The authors suggest that microdosing psychedelics alongside standard treatments might help restore these lost connections and improve symptoms that don’t respond well to current medications.

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Immunomodulatory functions of fungal melanins in respiratory infections

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Some dangerous fungi produce a dark pigment called melanin that acts like a cloak, protecting them from the body’s immune system. This review explains how melanin blocks multiple immune defenses, including suppressing warning signals to immune cells, preventing immune cells from engulfing and killing the fungi, and even absorbing harmful reactive molecules. Understanding these sneaky tactics could help scientists develop new treatments that strip away this protective cloak, making the fungi vulnerable to both the body’s natural defenses and antifungal drugs.

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Pathogenic mucorales: Deciphering their cell wall polysaccharidome and immunostimulatory potential

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Mucormycosis is a serious fungal infection that primarily affects people with weak immune systems and carries high mortality rates. Researchers studied three common mucormycosis-causing fungi to understand how their outer cell layers interact with the human immune system. They found that all three fungi trigger strong inflammatory responses, which may explain why the disease is so damaging. This research helps us better understand how these infections work and could lead to improved treatments or vaccines.

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Reprogramming astrocytic NDRG2/NF-κB/C3 signaling restores the diabetes-associated cognitive dysfunction

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This study found that regular exercise helps protect the brain of diabetic people from cognitive decline by boosting a protein called NDRG2 in astrocytes (brain support cells). The research shows that NDRG2 works by blocking harmful immune responses that damage synapses (connections between brain cells). In diabetic mice, exercise improved memory and learning ability while increasing NDRG2 levels, while blocking this protein reversed these benefits.

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Fungal β-Glucans: Biological Properties, Immunomodulatory Effects, Diagnostic and Therapeutic Applications

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β-glucans are natural substances found in yeast and fungi that help boost the immune system and fight cancer. They can be measured in blood to diagnose serious fungal infections and may help prevent common illnesses like colds and respiratory infections. Recent research suggests they could be useful additions to vaccines and may help patients recovering from COVID-19.

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