Compensatory mechanisms

SUB6 Subtilisin is Involved During the Initial Adhesion of Trichophyton benhamiae and T. mentagrophytes onto Reconstructed Human Epidermis

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Researchers studied a fungal protease called SUB6 produced by common skin infection-causing fungi. Using engineered fungi lacking this protein, they found that SUB6 helps fungi initially stick to skin but isn’t absolutely required for infection. The fungi can compensate by producing other proteases, suggesting SUB6 might be better used as a diagnostic marker to detect fungal infections rather than as a drug target.

SUB6 Subtilisin is Involved During the Initial Adhesion of Trichophyton benhamiae and T. mentagrophytes onto Reconstructed Human Epidermis

mycolabadmin

This study examined how a fungal protein called SUB6 helps dermatophytes (fungi causing ringworm) stick to human skin. Researchers used genetically modified fungi without SUB6 and found that these strains had difficulty initially attaching to skin but eventually infected it anyway. The results suggest SUB6 is a useful marker for detecting fungal infections but isn’t absolutely necessary for the fungus to cause disease.

Research Keyword: Compensatory mechanisms

SUB6 Subtilisin is Involved During the Initial Adhesion of Trichophyton benhamiae and T. mentagrophytes onto Reconstructed Human Epidermis

SUB6 Subtilisin is Involved During the Initial Adhesion of Trichophyton benhamiae and T. mentagrophytes onto Reconstructed Human Epidermis