Research Keyword: Coccidioidomycosis

Key Fungal Secreted Proteases in Coccidioidomycosis

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Researchers studied how a dangerous fungus called Coccidioides causes disease by examining special proteins called proteases that the fungus secretes. They found that blocking these proteases prevented the fungus from forming the spherule structures that allow it to spread inside infected people. This discovery could lead to new treatments for coccidioidomycosis, a serious infection that affects people in the Southwest United States.

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The impact of osteoarticular invasion by Coccidioides Sp disseminated infection

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A 48-year-old man from Mexico developed a serious fungal infection caused by Coccidioides, which spread from his lungs to his skin, bones, and joints, causing pain and swelling. Despite having a normally functioning immune system, he developed progressive disease that was initially misdiagnosed as rheumatoid arthritis. After switching to the antifungal medication fluconazole, his condition improved dramatically, with symptoms resolving within several months of treatment.

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Frequency, Interval, and Patient Factors Associated With Recurrence of Disseminated Cutaneous Coccidioidomycosis

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This study looked at how often a serious fungal skin infection called coccidioidomycosis comes back after treatment. Researchers found that about 25% of patients experienced at least one recurrence after stopping antifungal medications, with the average time before it returned being 14 months. Some patients had multiple recurrences, and most of the time the infection returned to the same location on the body.

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New epidemiological routes of Coccidioidomycosis in Mexico – the extension of this pathogen to new areas

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Coccidioidomycosis, a fungal lung disease traditionally found in desert regions of Mexico and the southwestern United States, is spreading to new areas where it was never seen before. Researchers tracked 122 cases between 1991 and 2023 and found that nearly half of the patients had no history of travel to known high-risk areas, suggesting the disease is becoming established in new locations. Climate change and drought conditions are likely helping the fungus expand its range, making it important for doctors everywhere to consider this disease when diagnosing respiratory infections.

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Impact of glycemic control on coccidioidomycosis outcomes in patients with underlying diabetes mellitus in central California

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This study examined how blood sugar control affects outcomes in patients with both diabetes and coccidioidomycosis, a fungal infection common in central California. Researchers found that patients with poorly controlled diabetes (higher HbA1c levels) had higher rates of serious lung disease with cavities and were less likely to recover from the infection. The study highlights that managing blood sugar levels may be just as important as taking antifungal medications when treating this dual condition.

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Extensive erythematous plaques of fungal origin in an overseas student: Cutaneous manifestation of coccidioidomycosis

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A 21-year-old student studying in Arizona developed unusual skin rashes months after returning to China. Doctors had difficulty diagnosing the condition because it lacked typical symptoms of the fungal infection coccidioidomycosis. By using multiple diagnostic methods including DNA sequencing and fungal culture, they identified the infection as caused by Coccidioides posadasii. When the initial antifungal drug didn’t work, testing showed the fungus was resistant, so they switched to a different antifungal called voriconazole, which successfully cured the infection after 12 months.

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