Research Keyword: CLSI standards

Prevalence and antifungal susceptibility profiles of Candida isolates among patients with candiduria: a multiplex PCR assay

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Researchers studied urinary tract infections caused by yeast (Candida species) in hospitalized patients. Using advanced molecular testing, they found that while the common yeast Candida albicans was most prevalent, other yeast species were increasingly showing resistance to antifungal medications, particularly to fluconazole. The study highlights the importance of identifying which specific yeast species is causing an infection to choose the most effective treatment.

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Cryptococcus albidus (Naganishia albida) meningitis in a young patient with T-cell acute lymphoblastic leukaemia

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A 16-year-old boy with leukemia developed meningitis caused by a rare fungus called Cryptococcus albidus. Doctors initially thought he had a viral infection and started him on antiviral medication, but specialized fungal tests revealed the true culprit. Treatment with antifungal medications successfully cured the infection, demonstrating the importance of identifying the exact cause of infection to provide the right treatment.

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Prevalence and antifungal susceptibility profiles of Candida isolates among patients with candiduria: a multiplex PCR assay

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This study examined Candida yeast infections in urine samples from hospitalized patients in Iran. Researchers identified seven different Candida species using a specialized PCR test and tested how well they responded to three antifungal medications. They found that while Candida albicans was most common, other species showed much higher resistance to fluconazole treatment. The findings highlight the importance of proper species identification for choosing the right treatment.

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Investigation of the antifungal activity of panobinostat, tamoxifen, and miltefosine alone and in combination with some conventional antifungal drugs against fluconazole-resistant Candida species

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Researchers tested whether three cancer drugs (panobinostat, tamoxifen, and miltefosine) could enhance the effectiveness of common antifungal medications against drug-resistant yeast infections. When combined with antifungals, some of these cancer drugs showed promise in killing resistant Candida species, though the effectiveness varied depending on which type of yeast was being treated. These findings suggest that combination therapies using already-approved drugs could help treat difficult fungal infections in cancer patients.

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Evaluation of antifungal effect of amphotericin B in comparison with nystatin on Candida species derived from patients undergoing head-and-neck radiotherapy

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This study compared two antifungal medications (nystatin and amphotericin B) for treating oral yeast infections in cancer patients receiving head-and-neck radiotherapy. Researchers tested how well each drug worked against different Candida yeast species before and during radiation treatment. The results showed that nystatin was more effective than amphotericin B at killing the yeasts, with nystatin working against all yeast species tested, while amphotericin B had reduced effectiveness against some Candida albicans strains.

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Molecular epidemiology, diversity, and antifungal susceptibility profiles of clinical and environmental mucorales: a five-year multicenter study in Iran (2018–2023)

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This research examined dangerous mold infections (Mucormycosis) that became more common after COVID-19. Scientists identified the types of molds causing these infections in Iran by testing 116 patient samples and 65 soil samples from across the country. They tested these molds against 13 different antifungal medications to find which drugs work best. The results showed that amphotericin B and posaconazole were the most effective medications, and patient samples were more susceptible to these drugs than environmental soil samples.

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Cryptococcus albidus (Naganishia albida) meningitis in a young patient with T-cell acute lymphoblastic leukaemia

mycolabadmin

A 16-year-old boy with blood cancer (T-ALL) developed a brain infection caused by a rare fungus called Cryptococcus albidus. Doctors initially thought he had a viral infection caused by herpes, but tests on his spinal fluid revealed the true fungal culprit. He was treated with antifungal medications that led to his recovery, emphasizing the importance of thorough testing when immunocompromised patients develop serious infections.

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