Clinical trial – Page 2

Interactions between classic psychedelics and serotonergic antidepressants: Effects on the acute psychedelic subjective experience, well-being and depressive symptoms from a prospective survey study

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This study examines how antidepressant medications (like SSRIs) affect the experience of classic psychedelics such as psilocybin and LSD. Researchers found that people taking these antidepressants experienced less intense emotional and mystical effects from psychedelics, but surprisingly, both groups showed similar improvements in mood and well-being several weeks later. This raises important questions about whether patients need to stop their antidepressants before using psychedelics therapeutically.

Knowledge, perceptions, and use of psychedelics for mental health among autistic adults: An online survey

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This survey studied how autistic adults feel about using psychedelics like psilocybin mushrooms for mental health. Nearly 70% of participants had tried psychedelics before and most found them helpful for anxiety and depression. Many participants were interested in trying them or participating in research, though legal and practical barriers stood in the way. The study suggests that psychedelics could be a promising treatment option for autistic people with mental health challenges.

An investigation of acute physiological and psychological moderators of psychedelic-induced personality change among healthy volunteers

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This study examined how a single high dose of psilocybin affects personality in healthy people. Participants who took psilocybin showed decreased anxiety-related personality traits (neuroticism) one month later. The effects were stronger in people who found the experience personally meaningful or who experienced more anxiety during the psychedelic state, suggesting that the intensity and meaning of the experience matters for lasting personality changes.

Research Progress on the Mechanisms of Polysaccharides against Gastric Cancer

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This review explores how natural polysaccharides from mushrooms, seaweed, plants, and traditional herbs can fight gastric cancer. These compounds work by triggering cancer cell death, stopping tumor growth, and boosting the body’s immune system. Unlike conventional chemotherapy drugs that cause serious side effects, these natural polysaccharides offer a safer alternative that can work alongside existing treatments to improve patient survival.

Engaging Mood Brain Circuits with Psilocybin (EMBRACE): a study protocol for a randomized, placebo-controlled and delayed-start, neuroimaging trial in depression

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This research study is investigating how psilocybin, a compound from certain mushrooms, affects the brain in people with depression. The study involves 50 participants who will receive either psilocybin or a placebo, with their brain activity monitored using advanced imaging scans. Researchers will examine how psilocybin changes blood flow and network activity in brain regions involved in mood regulation, and whether these changes are linked to improvements in depression symptoms.

A new highly digestible prescription diet containing Bacillus velezensis DSM 15544, fructo-oligosaccharides, plasma immunoglobulin, yeast and sepiolite for the management of acute diarrhea in dogs—a randomized double-blinded, controlled trial

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Dogs with sudden diarrhea often improve on their own, but a new specialized diet was tested to speed up recovery. The diet contained beneficial bacteria (Bacillus velezensis), fiber that feeds good bacteria (fructo-oligosaccharides), protective proteins from pork plasma, yeast, and a mineral that helps firm up stools. Dogs eating this special diet recovered in about 3-4 days compared to 6 days on a regular digestive diet, with 98% improving within a week versus only 66% with the control diet.

The phenomenology of psilocybin’s experience mediates subsequent persistent psychological effects independently of sex, previous experience, or setting

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A research study examined how psilocybin experiences affect long-term mental health and well-being in healthy volunteers. Participants received two doses of psilocybin in controlled medical settings while undergoing brain imaging. The study found that psilocybin consistently produced positive, lasting improvements in mood, well-being, and spiritual outlook, regardless of whether people had used psychedelics before, their sex, or the specific imaging setting used.

Safety, feasibility, tolerability, and clinical effects of repeated psilocybin dosing combined with non-directive support in the treatment of obsessive-compulsive disorder: protocol for a randomized, waitlist-controlled trial with blinded ratings

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This clinical trial is investigating whether psilocybin (a psychoactive compound found in certain mushrooms) combined with supportive counseling can help people with treatment-resistant obsessive-compulsive disorder. Researchers will give participants two doses of psilocybin while providing non-directive psychological support to help them process their experiences. The study aims to determine whether this approach is safe, tolerable, and effective at reducing OCD symptoms, and to understand the psychological mechanisms that might explain how it works.

Safety and efficacy of the swift microwave device in patients with mild-to-moderate onychomycosis: Protocol of an open-label, randomized, dose-finding pilot study

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This study evaluates a new microwave device (Swift System) as a potential treatment for fungal nail infections (onychomycosis). The device uses microwave energy to heat and eliminate fungal infections directly at the nail site, avoiding the side effects of oral medications. Researchers tested three different treatment schedules in 39 patients over 12 months to find the most effective dosing approach.

Crab vs. Mushroom: A Review of Crustacean and Fungal Chitin in Wound Treatment

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Chitin, a natural material found in crab shells and mushrooms, can be used to make wound dressings that speed up healing and fight infection. The review compares these two sources, finding that crab-derived chitin has been studied more extensively and has several commercial products available, while mushroom-derived chitin offers advantages like lower cost and easier processing. Both types work by promoting cell growth, stopping bleeding, and killing bacteria, making them promising alternatives to traditional wound dressings for treating difficult-to-heal wounds.

Research Keyword: Clinical trial