Research Keyword: clinical mycology

Contamination of fungal genomes of Onygenaceae (Phylum Ascomycota) in public databases: incidence, detection, and impact

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Scientists found that many fungal genome sequences stored in public databases contain unwanted bacterial DNA that can interfere with research results. They developed a method to identify and remove this contamination using related high-quality fungal genomes as reference. After cleaning four contaminated genomes, the quality improved significantly and the contamination dropped from 5-12% to below 3%, demonstrating that careful screening is essential for reliable genetic research.

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Rhinocerebral Mucormycosis in a Patient With Diabetes: A Rare but Critical Infection in the United Arab Emirates

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A middle-aged man with undiagnosed diabetes developed a serious fungal infection called mucormycosis that affected his sinuses, eyes, and brain. He presented with flu-like symptoms and facial weakness, and blood tests showed dangerously high blood sugar and acid levels (diabetic ketoacidosis). Doctors treated him with multiple rounds of antifungal medications, several surgeries, and innovative injections directly into and around his eyes and spinal cord, resulting in his successful recovery and discharge.

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De Novo Genome Assembly and Comparative Genome Analysis of the Novel Human Fungal Pathogen Trichosporon austroamericanum Type-Strain CBS 17435

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Scientists sequenced the complete genome of a dangerous fungal species called Trichosporon austroamericanum that can cause serious infections in humans, particularly transplant patients. Using advanced long-read sequencing technology, they assembled the organism’s 21 million base pair genome and compared it to a closely related fungal species. The analysis showed this species is genetically distinct and has interesting characteristics that help it survive at higher temperatures than most other fungi. This genetic information will help doctors and researchers better understand and treat infections caused by this emerging pathogenic yeast.

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Comparison of galactomannan lateral flow assay and enzyme immunoassay to identify Aspergillus spp. in bronchoalveolar lavage fluid

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Researchers compared two rapid tests for detecting a fungal infection called aspergillosis in lung fluid samples. One test uses a simple lateral flow format (like a COVID test), while the other is a more traditional enzyme immunoassay. Both tests had good agreement, with the lateral flow assay showing high accuracy and the advantage of being faster and requiring fewer laboratory resources, making it especially useful for hospitals with limited equipment.

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Five-Year Retrospective Analysis of Superficial Fungal Infections: Insights from Hospital Experience

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This study examined fungal skin infections in over 3,900 patients at a Serbian military hospital over five years. Researchers found that common fungi like Trichophyton mentagrophytes and T. rubrum caused most infections, with patterns varying by season, patient gender, and body location. Men were more likely to have foot infections while women showed more diverse fungal types. The findings suggest doctors should use more precise identification methods like MALDI-TOF testing to prescribe better treatments and help prevent recurring infections.

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Epidemiological profile of dermatophytes at the parasitology-mycology laboratory at Mohammed VI University Hospital in Oujda

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This study examined fungal skin infections caused by dermatophytes in a Moroccan hospital over four years, analyzing 950 samples. The researchers found that nail infections (onychomycosis) were most common, particularly in people over 50 years old, while scalp infections mainly affected children. The fungus Trichophyton rubrum was responsible for most infections, though Microsporum canis increasingly caused scalp infections, likely due to increased pet ownership in Morocco. The study emphasizes the importance of proper laboratory testing to identify the specific fungus and choose appropriate treatment.

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