Research Keyword: chromatin modification

Polycomb repressive complex 2 regulates sexual development in Neurospora crassa

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This research reveals how fungi control the timing of sexual reproduction using a molecular switch called PRC2. Like a safety lock on a complex machine, PRC2 keeps genes needed for fruiting body formation turned off until the right conditions occur (fertilization). When PRC2 stops working, fungi prematurely attempt to form reproductive structures even without a mating partner. This study shows how epigenetic control prevents wasteful development and ensures organisms reproduce only when conditions are favorable.

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The Gcn5 lysine acetyltransferase mediates cell wall remodeling, antifungal drug resistance, and virulence of Candida auris

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Candida auris is a dangerous fungal infection that resists many standard antifungal drugs. Researchers discovered that a protein called Gcn5 helps this fungus survive both drugs and the body’s immune system. By targeting Gcn5 with a new compound called CPTH2, scientists showed they could make the fungus more vulnerable to standard treatments like caspofungin, suggesting a promising new approach to fighting these infections.

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Natural probiotics improve heritable sterility

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Scientists discovered that some worms naturally carry mutations that cause progressive sterility across generations when raised in standard laboratory conditions. However, when these same worms are exposed to their naturally associated bacteria and parasites, they regain the ability to reproduce normally. This suggests that the microorganisms living with worms help regulate how genetic information is passed down through generations, and the bacteria diet can even create protective effects that last for multiple generations.

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