cell wall organization

Deubiquitinase Ubp5 is essential for pulmonary immune evasion and hematogenous dissemination of Cryptococcus neoformans

mycolabadmin

Researchers studied a protein called Ubp5 that helps the fungus Cryptococcus neoformans cause disease in humans. By removing this protein, the fungus became much less harmful and the immune system could fight it better. The fungus with the missing protein had problems with its outer coating, couldn’t hide as well from the immune system, and couldn’t spread to the brain. This suggests that blocking Ubp5 could be a new way to help the body defend against this dangerous fungal infection.

Kre6-dependent β-1,6-glucan biosynthesis only occurs in the conidium of Aspergillus fumigatus

mycolabadmin

Researchers discovered that a specific sugar compound called β-1,6-glucan is found in the spore-like reproductive structures (conidia) of the fungus Aspergillus fumigatus but not in its growing filaments (mycelium). Using advanced nuclear magnetic resonance technology, they identified the KRE6 gene as responsible for making this sugar and found that removing this gene makes the fungus more vulnerable to certain chemicals that damage fungal cell walls.

Research Keyword: cell wall organization

Deubiquitinase Ubp5 is essential for pulmonary immune evasion and hematogenous dissemination of Cryptococcus neoformans

Kre6-dependent β-1,6-glucan biosynthesis only occurs in the conidium of Aspergillus fumigatus