cell wall integrity – Page 2

Molecular Mechanisms of Pathogenic Fungal Virulence Regulation by Cell Membrane Phospholipids

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This review explains how the fats that make up fungal cell membranes directly influence how dangerous fungi become to humans. Different types of membrane fats help fungi change shape to invade tissues, survive stress in the body, and hide from immune cells. By understanding these processes, scientists can develop new ways to fight fungal infections by targeting the membrane components that fungi depend on for survival.

Integrated Transcriptomics–Proteomics Analysis Reveals the Response Mechanism of Morchella sextelata to Pseudodiploöspora longispora Infection

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White mold disease is a major problem for morel mushroom farmers in China. Researchers identified the fungus causing this disease and studied how morel cells defend themselves. Using advanced molecular techniques, they found that morel cells respond to infection by changing their cell membranes and walls, and by activating protective proteins that fight oxidative stress. This research helps explain how the disease damages morels and could lead to developing stronger, disease-resistant mushroom varieties.

A conserved fungal Knr4/Smi1 protein is crucial for maintaining cell wall stress tolerance and host plant pathogenesis

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Researchers discovered a fungal protein called Knr4 that is essential for fungal diseases in wheat crops. This protein helps fungi survive stress and cause disease. Importantly, this protein is found in many fungal pathogens but not in other organisms, making it an ideal target for developing new disease control strategies. When this protein is removed from fungal pathogens, they lose their ability to survive stress and infect plants, suggesting it could be used to combat fungal crop diseases.

Kinome analysis of Madurella mycetomatis identified kinases in the cell wall integrity pathway as novel potential therapeutic drug targets in eumycetoma caused by Madurella mycetomatis

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Eumycetoma is a serious fungal infection that causes large tumors under the skin and is very difficult to treat. Scientists used computer analysis to find special proteins called kinases in the fungus that might be good targets for new drugs. They discovered that proteins involved in the fungus’s cell wall are promising targets, which could lead to better treatments for this neglected disease.

Cell wall remodeling in a fungal pathogen is required for hyphal growth into microspaces

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Researchers discovered how fungi squeeze through tiny spaces inside plant tissues to cause disease. They found that fungi need to soften and remodel their cell walls to reduce their width and fit through spaces that are much narrower than normal fungal filaments. This ability to change shape is critical for the fungus to invade and colonize plants, ultimately causing wilting diseases in crops like tomatoes.

Differential responses of Cacao pathogens Colletotrichum gloeosporioides and Pestalotiopsis sp. to UVB 305 nm and UVC 275 nm

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Scientists studied how UV light can be used to fight fungal diseases that harm cacao plants. They found that UVC light (a type of ultraviolet radiation) is much more effective at killing these fungi than UVB light. Some fungi were very resistant to UV treatment, but the researchers discovered that combining UV light with sound waves (sonication) could overcome this resistance, offering a chemical-free way to protect crops.

Analysis of the chitin synthase gene family in Ganoderma lucidum: its structure, phylogeny, and expression patterns

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Scientists studied eight chitin synthase genes in Ganoderma lucidum (reishi mushroom), which are important for building the fungal cell wall and controlling growth. They found that different genes are active at different stages of mushroom development and that six of these genes become more active when exposed to high temperatures, suggesting they help the mushroom survive heat stress. This research helps us understand how mushrooms grow and develop, which could lead to better cultivation methods.

Inhibitory Effects and Mechanisms of Perilla Essential Oil and Perillaldehyde against Chestnut Pathogen Botryosphaeria dothidea

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Chestnuts often rot during storage due to fungal infection. This study found that oil extracted from perilla leaves, particularly a compound called perillaldehyde, effectively prevents the fungus Botryosphaeria dothidea from growing. The antifungal compounds work by breaking down the protective layers of the fungal cells, causing them to leak and die. When applied to stored chestnuts, this natural oil significantly extends their shelf life without harming human health.

Transcription factor RonA-driven GlcNAc catabolism is essential for growth, cell wall integrity, and pathogenicity in Aspergillus fumigatus

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Researchers identified how a deadly fungus called Aspergillus fumigatus uses a special nutrient (GlcNAc) to survive and cause disease. They found that a protein called RonA controls this nutrient processing and also helps the fungus hide from the immune system by building a protective outer coating. When RonA is disabled, the fungus becomes much less dangerous because the immune system can recognize it better. This discovery suggests RonA could be a new target for developing antifungal drugs.

Gene fusion and functional diversification of P450 genes facilitate thermophilic fungal adaptation to temperature change

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Researchers discovered that a thermophilic fungus uses two special genes to adapt to temperature changes. One of these genes is uniquely fused from two different genes, creating a hybrid protein with multiple functions. These genes help the fungus produce iron-binding molecules that stabilize its structure and support its growth when temperatures drop, allowing the fungus to survive in environments from compost piles to stored grains.

Research Keyword: cell wall integrity