Research Keyword: cell wall glycoproteins

Glycan microarray analysis of Candida-related antibodies in human and mice sera guides biomarker discovery and vaccine development

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Researchers used a special microarray technology to identify immune responses in blood samples from people infected with Candida yeast. They found that early infections trigger antibodies against certain sugar structures, while later infections produce different antibodies. Three specific sugar molecules showed promise as markers for diagnostic tests and vaccine development against dangerous yeast infections.

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Phospholipase PlcH is involved in the secretion of cell wall glycoproteins and contributes to the host immune response of Aspergillus fumigatus

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Researchers discovered that an enzyme called PlcH helps a dangerous mold called Aspergillus fumigatus release protective proteins into its cell wall. These proteins help the fungus survive and evade the immune system. When scientists removed the gene for PlcH, the fungus became weaker and more vulnerable to both antifungal drugs and immune cells, suggesting PlcH could be a target for new antifungal treatments.

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