Research Keyword: cell wall biogenesis

Functions of the Three Common Fungal Extracellular Membrane (CFEM) Domain-Containing Genes of Arthrobotrys flagrans in the Process of Nematode Trapping

Researchers studied how a fungus called Arthrobotrys flagrans catches and kills parasitic worms. They found that three genes containing a special protein domain called CFEM control how the fungus produces sticky traps and deadly proteins. By studying mutant fungi with these genes deleted or overexpressed, they discovered that these genes work together and can compensate for each other, helping explain how this fungus could be used as a natural pest control for harmful nematodes.

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Drug repurposing to fight resistant fungal species: Recent developments as novel therapeutic strategies

This editorial highlights the growing problem of fungal infections that resist current treatments, causing millions of deaths worldwide each year. Researchers are finding new ways to fight these resistant infections by repurposing existing drugs in new combinations and discovering novel compounds from natural sources. The collection of studies presented shows promising results using combinations like minocycline with antifungal drugs, natural compounds like baicalin, and AI technology to predict resistance patterns. These innovative approaches offer hope for better treatment options for patients suffering from serious fungal infections.

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Functions of the Three Common Fungal Extracellular Membrane (CFEM) Domain-Containing Genes of Arthrobotrys flagrans in the Process of Nematode Trapping

Arthrobotrys flagrans is a fungus that acts as a natural pest controller by trapping and killing parasitic nematodes that damage crops and livestock. Scientists studied three key genes in this fungus that contain CFEM protein domains and found they are critical for forming sticky traps and controlling how deadly the fungus is to nematodes. The research shows that when certain CFEM genes are removed, the fungus produces stickier traps and kills more nematodes, while removing other CFEM genes has the opposite effect, providing insights for developing better biocontrol products.

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