Research Keyword: cell factory

The forced activation of asexual conidiation in Aspergillus niger simplifies bioproduction

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Researchers developed a new method to simplify the production of L-malic acid using genetically modified Aspergillus niger fungi. Instead of growing spores on solid plates—a time-consuming and labor-intensive process—they engineered the fungi to produce spores directly in liquid medium controlled by adding xylose. This simplified approach maintains the fungi’s ability to produce high levels of L-malic acid while significantly reducing costs and labor requirements for industrial production.

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Understanding and controlling filamentous growth of fungal cell factories: novel tools and opportunities for targeted morphology engineering

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Fungi are used in industry to produce medicines, chemicals, and enzymes in large fermentation tanks. However, the way these fungal cells grow and clump together greatly affects how much product they make, but scientists don’t yet fully understand or control this growth. This review discusses new tools like genetic engineering, computer modelling, and special imaging techniques that are helping researchers better understand and control fungal growth patterns to improve industrial production.

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Towards engineering agaricomycete fungi for terpenoid production

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Mushroom-forming fungi, particularly species like shiitake and oyster mushrooms, naturally produce valuable compounds called terpenoids used in medicines, food, and cosmetics. Scientists are learning to genetically engineer these fungi to produce even larger amounts of these beneficial compounds, potentially making them as important to biotechnology as baker’s yeast and mold have been historically. This could create new sustainable sources for medicinal compounds and industrial chemicals.

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