Overexpression of efflux pump and biofilm associated genes in itraconazole resistant Candida albicans isolates causing onychomycosis
mycolabadmin
Nail fungal infections caused by Candida albicans can be difficult to treat when the fungus becomes resistant to common antifungal medications like itraconazole. Researchers found that resistant strains have overactive genes that pump the drug out of fungal cells and genes that help the fungus form protective biofilm structures. Understanding these resistance mechanisms could lead to better combination treatments that block these protective strategies.