Research Keyword: Candida tropicalis

Clinical Isolate of Candida tropicalis from a Patient in North Carolina: Identification, Whole-Genome Sequence Analysis, and Anticandidal Activity of Ganoderma lucidum

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Researchers in North Carolina identified a drug-resistant yeast infection (Candida tropicalis) from a hospital patient and tested whether extracts from reishi mushrooms (Ganoderma lucidum) could kill it. Using genetic analysis, they found mutations in the yeast that help it resist antifungal drugs. All three types of mushroom extracts tested successfully stopped the yeast’s growth and damaged its cells, suggesting that reishi mushrooms could be a promising natural treatment option for hard-to-treat candida infections.

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Ploidy plasticity drives fungal resistance to azoles used in agriculture and clinics

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Agricultural fungicides called azoles can cause fungi to change their genetic makeup in ways that make them resistant to medical antifungal drugs. Researchers found that when Candida tropicalis (a fungal pathogen) is exposed to tebuconazole, an agricultural fungicide, it can transform into a haploid form (with half the normal chromosomes) that is resistant to both agricultural and clinical azoles. This discovery helps explain why fungal infections are becoming harder to treat in hospitals.

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Candida tropicalis Fungal Keratitis: A Case Report and Literature Review

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A 66-year-old patient with a long history of corneal problems developed a serious eye infection caused by a fungus called Candida tropicalis. Doctors identified the infection through laboratory tests and treated it successfully with antifungal medications. This is the first documented case of this particular fungal infection in Morocco and highlights the importance of testing for fungal infections in patients with existing eye problems.

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Ploidy plasticity drives fungal resistance to azoles used in agriculture and clinics

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Researchers discovered that a common agricultural fungicide can cause fungal cells to change their genetic structure in ways that make them resistant to medicines used to treat human infections. The fungus Candida tropicalis can switch to a haploid state (single copy of genes instead of two) when exposed to this agricultural chemical, and these altered cells become resistant to both agricultural and medical antifungal drugs. This explains how resistance that develops in agricultural settings can spread to clinical settings, creating a public health threat.

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Ploidy plasticity drives fungal resistance to azoles used in agriculture and clinics

mycolabadmin

Agricultural fungicides can cause fungal pathogens like Candida tropicalis to change their genetic structure and become resistant to clinical antifungal drugs. When exposed to agricultural azole fungicides, these fungi can shift from their normal two-copy genetic state to a one-copy state, making them harder to treat with hospital medicines. This study reveals how the same drugs used on farms can create dangerous drug-resistant fungi that threaten human health.

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Antifungal activity and mechanism of novel peptide Glycine max antimicrobial peptide (GmAMP) against fluconazole-resistant Candida tropicalis

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Scientists developed a new antimicrobial peptide called GmAMP that can effectively kill drug-resistant fungal infections caused by Candida tropicalis, a pathogen resistant to common antifungal medications. The peptide works by damaging the fungal cell membrane and is safe for human use. In laboratory tests using insect larvae, the peptide successfully treated infections and reduced the fungal burden, suggesting it could become a new treatment option for patients with resistant fungal infections.

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