Research Keyword: candida infection

A Case Report of Candidiasis Cellulitis in Long-Term Corticosteroid Use

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A 54-year-old man developed a serious skin infection on his hand caused by Candida, a normally harmless fungus, because he had been taking corticosteroid injections for 15 years for breathing problems. Despite antibiotic treatment, the swelling and pain continued. Doctors discovered it was a fungal infection through lab tests and treated it with antifungal medication (fluconazole) after draining the infection, which completely healed within two weeks.

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Metabolic Patterns of Fluconazole Resistant and Susceptible Candida auris Clade V and I

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Researchers used advanced chemical analysis to identify different compounds produced by a dangerous fungus called Candida auris that can cause serious infections. They compared fungal strains that were resistant to the antifungal drug fluconazole with those that were susceptible, finding that resistant strains produced different metabolites (chemical compounds) than susceptible ones. These findings could help doctors develop better treatments by identifying what makes this fungus resistant to current medications.

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Acute fungal endometritis in women with abnormal uterine bleeding: Clinical and microbiological insights

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This study examined a rare fungal infection of the uterus called fungal endometritis that causes abnormal bleeding and discomfort in women. Researchers found that about 12% of women with unexplained abnormal bleeding had this fungal infection, which was caused by different species of Candida yeast. A simple test using vaginal swabs was not effective for diagnosis; instead, doctors needed to take samples directly from the uterine lining. Treatment with an antifungal medication called voriconazole combined with surgical cleaning was successful in all cases studied.

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A broad-spectrum anti-fungal effector dictates bacterial-fungal interkingdom interactions

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Scientists discovered that a common soil bacterium called Acidovorax citrulli has a sophisticated weapon to fight dangerous fungi. This bacterium uses a needle-like structure to inject a toxic protein called TseN directly into fungal cells, where it damages the fungal DNA and causes death. This new discovery is particularly exciting because it works against drug-resistant fungi like Candida auris that are increasingly hard to treat. Tests in mice confirmed that this bacterial attack significantly reduces fungal infections on skin.

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