Research Keyword: cancer stem cells

Lentinan inhibits colorectal cancer stemness by binding CD133 and suppressing the CD133/p85/p-AKT signaling axis

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Researchers discovered that lentinan, a natural compound from shiitake mushrooms, can specifically target and kill cancer stem cells in colorectal cancer by binding to a protein called CD133. This is significant because cancer stem cells are the reason why cancers come back even after treatment. By blocking a specific pathway these cells use to survive, lentinan may help prevent cancer recurrence and reduce the side effects associated with traditional chemotherapy.

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Methods for Overcoming Chemoresistance in Head and Neck Squamous Cell Carcinoma: Keeping the Focus on Cancer Stem Cells, a Systematic Review

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Head and neck cancer is often resistant to chemotherapy because of cancer stem cells that survive treatment and cause recurrence. This review examined 31 studies on methods to overcome this resistance, finding that natural products like mushrooms (Ganoderma lucidum), plants (sulforaphane from broccoli, curcumin from turmeric), and synthetic compounds can enhance chemotherapy effectiveness when combined with traditional drugs. These approaches work by targeting the specific pathways that allow cancer stem cells to survive, potentially improving treatment outcomes while reducing required drug doses and side effects.

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A Novel Erinacine S Derivative from Hericium erinaceus Overcomes Chemoresistance in Colorectal Cancer Cells by Enhancing TRAIL/TNFR1/DR5 Expression through Histone Acetylation

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This study shows that erinacine S, a natural compound from Lion’s Mane mushrooms, can help overcome drug resistance in colorectal cancer cells. The compound works by activating pathways that trigger cancer cell death and by modifying how genes are expressed at the molecular level. In both laboratory experiments and animal models, erinacine S successfully stopped tumor growth and killed resistant cancer cells, suggesting it could be a promising natural treatment for patients with hard-to-treat colorectal cancer.

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A Novel Erinacine S Derivative from Hericium erinaceus Overcomes Chemoresistance in Colorectal Cancer Cells by Enhancing TRAIL/TNFR1/DR5 Expression through Histone Acetylation

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Researchers found that erinacine S, a compound from Lion’s Mane mushroom, can help kill colorectal cancer cells that have become resistant to chemotherapy drugs. The compound works by activating death pathways in cancer cells and modifying how genes are expressed. In mouse studies, erinacine S significantly reduced tumor growth compared to standard chemotherapy alone. This suggests Lion’s Mane mushroom derivatives could potentially be developed as a natural treatment option for patients with drug-resistant colorectal cancer.

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Harnessing Natural Products to Surmount Drug Resistance in Gastric Cancer: Mechanisms and Therapeutic Perspectives

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Gastric cancer is a serious disease that often becomes resistant to chemotherapy drugs, making treatment difficult. This review examines how natural products found in plants and herbs can help overcome this drug resistance. These natural compounds work through multiple mechanisms, including targeting cancer stem cells, boosting the immune system, and enhancing the effectiveness of standard chemotherapy treatments.

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