Research Keyword: cancer cytotoxicity

From Mushrooms to Molecules: Exploring Depsidones in Ganoderma lucidum for Antioxidant and Anticancer Applications

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Researchers studied a medicinal mushroom called Ganoderma lucidum to identify compounds that could fight cancer. They found nine rare compounds called depsidones that showed promise against different types of cancer cells, including liver, colon, breast, and lung cancer. The compounds were shown to work by binding to cancer-related proteins, suggesting they could be developed into new cancer treatments.

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Chemical Content and Cytotoxic Activity on Various Cancer Cell Lines of Chaga (Inonotus obliquus) Growing on Betula pendula and Betula pubescens

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This study examined chaga mushroom, a traditional medicine used against cancer, grown on two types of birch trees. Researchers tested chaga extracts on 31 different cancer cell types and found they were moderately effective at inhibiting cancer cell growth, particularly against liver and thyroid cancers. The chaga from silver birch (B. pendula) worked slightly better than that from downy birch (B. pubescens) due to higher levels of a compound called inotodiol.

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Changes in Functionality of Tenebrio molitor Larvae Fermented by Cordyceps militaris Mycelia

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Scientists fermented mealworms (a sustainable food source) with a medicinal fungus called Cordyceps militaris to make them more nutritious and appealing. The fermented mealworms had much higher protein, fiber, and a cancer-fighting compound called cordycepin compared to regular mealworms. This technique creates a healthier, more environmentally friendly alternative protein food that could help feed growing populations while reducing the environmental impact of traditional livestock farming.

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Localization of Secondary Metabolites in Relict Gymnosperms of the Genus Sequoia In Vivo and in Cell Cultures In Vitro, and the Biological Activity of Their Extracts

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Researchers studied an ancient giant redwood tree species to extract valuable medicinal compounds. They successfully grew Sequoia cells in laboratory culture that produced powerful cancer-fighting and antifungal substances. These extracts showed promise against cervical cancer and brain tumor cells while being safe to normal cells, offering a sustainable way to harvest these compounds without damaging wild redwood populations.

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