calcium signaling – mycolab.ai

The molecular mechanisms through which psilocybin prevents suicide: evidence from network pharmacology and molecular docking analyses

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Researchers used computer-based analysis to understand how psilocybin, a compound found in certain mushrooms, might help prevent suicide. They identified four key proteins that psilocybin interacts with and found that it works through serotonin and calcium signaling pathways in the brain, which are known to be involved in depression and suicidal behavior. While these findings are promising, more research is needed to confirm these effects in humans before psilocybin can be used clinically for suicide prevention.

Emerging paradigms for target discovery of traditional medicines: A genome-wide pan-GPCR perspective

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Traditional medicines from plants, animals, and fungi contain chemical compounds that can interact with specific proteins in our cells called G protein-coupled receptors (GPCRs). These receptors control many important body functions and are targeted by about one-third of all FDA-approved medications. This review explains how scientists are discovering new therapeutic compounds from traditional medicines by systematically screening them against the complete library of human GPCRs, using advanced techniques to identify which compounds bind to which receptors. Famous examples include morphine from poppies for pain relief and compounds from ginseng that help regulate blood sugar.

Research Keyword: calcium signaling

The molecular mechanisms through which psilocybin prevents suicide: evidence from network pharmacology and molecular docking analyses

Emerging paradigms for target discovery of traditional medicines: A genome-wide pan-GPCR perspective