Research Keyword: calcium imaging

Multiphoton imaging of neural structure and activity in Drosophila through the intact cuticle

Scientists developed a new imaging technique that allows researchers to observe brain activity in fruit flies without surgically removing the protective head covering. This breakthrough lets researchers watch neural activity for much longer periods and during natural behaviors like walking and responding to odors. The technique uses special microscopes that shine infrared light through the fly’s intact head to image neurons expressing fluorescent proteins.

Read More »

A dopamine-gated learning circuit underpins reproductive state-dependent odor preference in Drosophila females

Female fruit flies change their food preferences after mating, becoming attracted to nutrients important for egg production. This study reveals that during mating, pheromone detection triggers dopamine-driven changes in the fly’s brain learning center. These neural changes essentially ‘remember’ mating experience and reprogram the female’s sense of smell, even though the sensory neurons return to normal within hours. This demonstrates how an animal can learn from mating experience to make better nutritional choices as a mother.

Read More »

Precise Magnetic Stimulation of the Paraventricular Nucleus Improves Sociability in a Mouse Model of ASD

Researchers developed a new magnetic stimulation technique using tiny iron nanoparticles to precisely target a specific brain region called the paraventricular nucleus. When stimulated at 10 Hz, this region releases oxytocin, a hormone that improves social behavior. In mice with autism-like symptoms, one week of this treatment significantly improved their sociability and reduced anxiety, offering a promising non-invasive therapy for autism.

Read More »

Taste cues elicit prolonged modulation of feeding behavior in Drosophila

This study shows that fruit flies can remember tastes they recently experienced and adjust their future feeding behavior based on these memories. After tasting something sweet, flies become more likely to feed in the next few seconds, while tasting something bitter makes them less likely to feed. Interestingly, nerve cells must remain active even after the taste is gone to maintain this memory, suggesting the brain stores taste information in a special way.

Read More »
Scroll to Top