Research Keyword: C-type lectin receptors

Dectin-1 and dectin-2 drive protection against Sporothrix brasiliensis in experimental sporotrichosis

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Scientists studied how the immune system fights a dangerous fungal infection called sporotrichosis caused by Sporothrix brasiliensis. They found that two immune receptors called dectin-1 and dectin-2 are crucial for fighting this infection by activating specific killer T cells and preventing immune suppression. Unlike what was previously thought, these receptors don’t work mainly by triggering inflammation, but rather by fine-tuning the balance of different immune cell types. This discovery could help develop new treatments for this emerging fungal disease.

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Dectin-1 and dectin-2 drive protection against Sporothrix brasiliensis in experimental sporotrichosis

mycolabadmin

Researchers studied how the body fights a dangerous fungus called Sporothrix brasiliensis that causes sporotrichosis. They found that two immune receptors called dectin-1 and dectin-2 are crucial for protecting against this infection in mice. Surprisingly, these receptors work by activating killer immune cells and controlling regulatory immune cells, rather than through the typical immune response pathway scientists expected.

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Dectin-1 and dectin-2 drive protection against Sporothrix brasiliensis in experimental sporotrichosis

mycolabadmin

Scientists studied how the body’s immune system defends against Sporothrix brasiliensis, a dangerous fungus spreading through Latin America. They found that two immune receptors called dectin-1 and dectin-2 are crucial for fighting this infection by activating killer T cells and controlling regulatory T cells. Surprisingly, a cytokine called IL-17, commonly associated with fungal defense, actually helps maintain tissue integrity rather than directly killing the fungus.

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Role of Candida species in pathogenesis, immune regulation, and prognostic tools for managing ulcerative colitis and Crohn’s disease

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This article explores how fungi, particularly Candida species, contribute to inflammatory bowel diseases like Crohn’s disease and ulcerative colitis. The fungal microbiota becomes imbalanced in IBD patients, triggering harmful immune responses and worsening inflammation. The researchers propose that measuring specific Candida levels could help doctors diagnose disease severity and predict treatment response, opening new possibilities for personalized IBD management.

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The C-type lectin receptor Dcir (Clec4a2) restrains Aspergillus fumigatus elimination by limiting the degranulatory activity of neutrophils

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This study reveals that a receptor called Dcir on immune cells called neutrophils actually prevents effective killing of the fungus Aspergillus fumigatus by limiting the release of antibacterial granules. When researchers removed Dcir from mice, their neutrophils became more effective at fighting the fungal infection. This suggests that blocking Dcir might help patients with fungal respiratory infections clear the pathogen more effectively.

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