bronchoalveolar lavage fluid

The Inhibitory Effects of Cordyceps militaris ARA301 Extract on Lipopolysaccharide-Induced Lung Injury in vivo

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Researchers tested a mushroom extract from Cordyceps militaris to see if it could protect mice from lung injury caused by bacterial toxins. The extract successfully reduced inflammation, prevented excessive mucus production, and decreased immune cell buildup in the lungs. These findings suggest that this mushroom extract could potentially be used as a natural supplement to help prevent respiratory diseases and support lung health.

Differential composition of the pulmonary microbiome in HIV-positive versus HIV-negative patients with Pneumocystis jirovecii

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This study compared lung infections in HIV-positive and HIV-negative patients who both had Pneumocystis jirovecii. Researchers found that HIV-positive patients had more diverse microorganisms in their lungs, particularly viruses, yet generally did better. HIV-negative patients had fewer types of microorganisms but worse outcomes. The findings suggest that the way a person’s immune system is weakened matters more than just having many germs present.

Time- and temperature-dependent Pentraxin 3 stability in serum and bronchoalveolar lavage fluid samples

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Researchers tested how well Pentraxin 3, a protein that helps detect fungal infections, stays stable when stored under different conditions. They found that this protein remains reliable when kept frozen at cold temperatures (like in a freezer) for up to several months or even years, but breaks down quickly when stored at body temperature. These findings help doctors and laboratories know how to properly store and test patient samples to accurately diagnose serious fungal infections.

The diagnosis of mucormycosis by PCR in patients at risk: a systematic review and meta-analysis

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This study evaluated how well PCR blood tests and tissue samples can diagnose a serious fungal infection called mucormycosis. Researchers analyzed 30 previous studies and found that PCR testing works very well, especially on respiratory fluid samples. Blood tests showed good accuracy too and could be useful for screening high-risk patients without requiring invasive procedures. The findings suggest PCR should become a standard diagnostic method for this difficult-to-diagnose infection.

Time- and temperature-dependent Pentraxin 3 stability in serum and bronchoalveolar lavage fluid samples

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Researchers tested how stable Pentraxin 3, a protein marker for fungal infections, remains when stored under different conditions. They found that samples stored in freezers at −20°C or −80°C kept stable for months, making Pentraxin 3 a reliable marker for diagnosing serious fungal infections. However, samples stored at warm temperatures degraded quickly, so proper cold storage is essential for accurate test results.

Acute Respiratory Distress Syndrome Due to COVID-19-Associated Pulmonary Aspergillosis with Rare Extensive Tracheobronchial Pseudomembranous Involvement: A Case Report

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An 87-year-old man with COVID-19 developed a rare and severe fungal infection in his airways caused by Aspergillus fumigatus. Doctors used a camera tube (bronchoscope) to see thick, yellowish-white membrane-like material coating his entire windpipe and airways, which is an extremely rare complication. Despite starting antifungal medications, his condition rapidly worsened leading to organ failure and death. This case highlights how COVID-19 can leave patients vulnerable to serious secondary fungal infections that require immediate recognition and treatment.

Fluconazole worsened lung inflammation, partly through lung microbiome dysbiosis in mice with ovalbumin-induced asthma

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Fluconazole is an antifungal medication that works well for treating asthma caused by fungal infections, but may actually worsen asthma from other causes. In mice with allergic asthma, fluconazole killed beneficial bacteria and promoted the growth of harmful bacteria that increased inflammation. This study suggests that fluconazole should only be used for fungal-related asthma and careful monitoring is needed if used in patients with regular asthma.

Time- and temperature-dependent Pentraxin 3 stability in serum and bronchoalveolar lavage fluid samples

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This study investigated how stable Pentraxin 3 (Ptx3), a protein used to detect fungal infections, remains when stored at different temperatures. Researchers found that Ptx3 stays reliable for up to 8 months in freezer storage at −20°C and even longer at −80°C, making it a dependable biomarker for diagnosing serious fungal infections. However, storing samples at room temperature (37°C) causes the protein to break down quickly, so proper cold storage is essential for accurate test results.

Research Keyword: bronchoalveolar lavage fluid