Box-Behnken design – Page 2

Optimization of triterpenoids biosynthesis in Athelia termitophila as a source of natural products

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Researchers optimized growing conditions for a parasitic termite fungus called Athelia termitophila to produce more triterpenoids, which are medicinal compounds with health benefits. By systematically testing different nutrients and fermentation parameters, they increased triterpenoid production by 1.9 times and fungal biomass by 1.66 times. This breakthrough makes it more practical and cost-effective to produce these natural compounds for use in pharmaceuticals and functional foods.

Modelling the Combined Effects of Oxalic Acid, Water Activity, and pH on the Growth and Mycotoxin Production of Aspergillus spp. in a Dried Fig System

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Dried figs can become contaminated with harmful fungi that produce dangerous toxins during the drying process. Researchers used mathematical modeling to understand how water content, acidity, and oxalic acid treatment affect fungal growth and toxin production in figs. They found that reducing water content is the most effective way to prevent dangerous toxin buildup. These models help the fig industry identify and avoid conditions that promote contamination, ultimately making dried figs safer for consumers.

Design and test analysis of a rotary cutter device for root cutting of golden needle mushroom

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This study develops a specialized high-speed cutting machine for harvesting golden needle mushrooms, which are currently picked by hand due to their delicate nature. The machine uses a fast-spinning blade with a special sliding angle that cuts smoothly rather than crushing the tender stems, similar to how a sharp knife slides through vegetables rather than crushing them. Testing showed this approach reduces energy use and damage while improving cutting quality, making mushroom harvesting more practical for commercial scale operations.

Optimization of triterpenoids biosynthesis in Athelia termitophila as a source of natural products

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Researchers optimized growing conditions for a fungus found in termite nests to dramatically increase production of triterpenoids, naturally-occurring compounds with potent health benefits. Using statistical methods to test different nutrients and conditions, they nearly doubled triterpenoid production and mycelial biomass. These findings could make triterpenoid-based medicines and supplements more affordable and widely available by improving natural production methods.

Optimisation and Characterisation of Novel Angiotensin-Converting Enzyme Inhibitory Peptides Prepared by Double Enzymatic Hydrolysis from Agaricus bisporus Scraps

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Scientists discovered three new peptides in common button mushroom scraps that can lower blood pressure by blocking an enzyme called ACE. Using special enzymes to break down mushroom proteins and then purifying the result, they created peptides with strong blood pressure-lowering activity that survive stomach digestion well. This finding turns mushroom waste into a valuable source for making natural blood pressure medications that are safer than synthetic alternatives.

Design and test analysis of a rotary cutter device for root cutting of golden needle mushroom

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Golden needle mushrooms are delicate fungi currently harvested by hand because traditional cutting machines damage them. Researchers designed a new high-speed rotating blade device that cuts mushroom roots cleanly and efficiently by using fast spinning cuts that minimize compression damage. The optimized machine reduces energy use by nearly 25% while improving cutting quality, making mushroom farming more practical and efficient.

Optimized Extraction of Bioactive Polysaccharides from Wild Mushrooms: Toward Enhanced Yield and Antioxidant Activity

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Scientists optimized how to extract healthy compounds called polysaccharides from three wild mushroom species found in European forests. Using hot water extraction with carefully controlled temperature, time, and water amounts, they found that each mushroom type had different optimal conditions for getting the most beneficial compounds. The extracted polysaccharides showed strong antioxidant properties and could be used to develop new functional foods or supplements.

Study on Optimization of Liquid Fermentation Medium and Antitumor Activity of the Mycelium on Phyllopora lonicerae

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Scientists optimized how to grow Phylloporia lonicerae fungus in the lab, increasing its production by 142% while cutting growth time by two-thirds. They discovered that certain compounds extracted from this fungus, particularly from a petroleum ether extract, can kill cancer cells and trigger apoptosis. The petroleum ether extract was more effective than the standard cancer drug 5-fluorouracil, especially against esophageal cancer cells, suggesting this fungus could be developed into a natural anti-cancer treatment.

Optimising Chlorella vulgaris bioflocculation by Aspergillus Niger pellets and their application in wastewater treatment and lipid production

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This research demonstrates an innovative approach to cleaning wastewater using a combination of algae and fungal pellets. The scientists optimized conditions for growing Aspergillus niger fungi as compact pellets that can efficiently trap and harvest microscopic algae cells. When these fungal-algae pellets were used to treat wastewater, they removed over 90% of harmful nutrients like ammonium and phosphate, making it a cost-effective and environmentally friendly alternative to traditional water treatment methods.

Study on Optimization of Liquid Fermentation Medium and Antitumor Activity of the Mycelium on Phyllopora lonicerae

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Researchers improved the production of a medicinal fungus called Phylloporia lonicerae that grows on honeysuckle plants. They developed a better growing medium that produced more fungus in less time. They then discovered that components from this fungus can kill cancer cells, particularly lung and esophageal cancer cells, by triggering a natural cell death process called apoptosis. This work suggests the fungus could be developed into an anti-cancer functional food.

Research Keyword: Box-Behnken design