Box-Behnken design – mycolab.ai

Development and preliminary mechanistic analysis of compound effervescent hepatoprotective granules

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Researchers developed a new health product combining three medicinal plants to protect the liver from injury. The mixture contains effective compounds that reduce liver inflammation, fight harmful oxidative stress, and protect liver cells from damage. Studies in rats showed the product improved liver function and reduced markers of liver damage, suggesting it could be useful for preventing and treating liver injuries caused by drugs, alcohol, or toxins.

Extraction Optimization and Bioactivity of Polysaccharides from Ganoderma leucocontextum Spores

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Researchers developed an improved method to extract beneficial polysaccharides from Ganoderma leucocontextum (white Ganoderma), a rare mushroom from the Tibetan plateau. The extracted compound GLSP-A1 showed strong anti-inflammatory effects by reducing inflammatory markers and reduced signs of aging in test organisms by decreasing harmful reactive oxygen species and cellular aging pigments. This work suggests the mushroom polysaccharide could potentially be used in dietary supplements to help slow aging.

Optimization of the Decolorization of the Reactive Black 5 by a Laccase-like Active Cell-Free Supernatant from Coriolopsis gallica

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Textile factories produce large amounts of colored wastewater containing harmful dyes like Reactive Black 5. Researchers optimized an enzyme-based treatment using laccase from a fungus called Coriolopsis gallica to remove these dyes from water. By carefully balancing enzyme concentration, pH, temperature, and a chemical booster called HBT, they achieved 82% dye removal in just 2 hours, offering a cleaner and more environmentally friendly alternative to traditional chemical treatments.

Valorization of Hericium erinaceus By-Products for β-Glucan Recovery via Pulsed Electric Field-Assisted Alkaline Extraction and Prebiotic Potential Analysis

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This research shows how scientists can extract beneficial compounds called β-glucans from leftover Lion’s Mane mushroom material using electrical pulses and alkaline treatment. These extracted compounds work like prebiotics, feeding and promoting the growth of beneficial bacteria in your gut, which then produce healthy fatty acids that support digestive health. The method is environmentally friendly and could help food companies make functional ingredients from mushroom waste.

From consortium design to bioaugmented filters: scalable yeast-based strategies for lead remediation in water systems

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Lead contamination in water is a serious health problem worldwide. This research developed a solution using natural yeast strains from a river that can remove lead from water. Scientists optimized three different yeast types to work together and incorporated them into filters, achieving up to 99.97% lead removal. This sustainable, low-cost approach could make clean water more accessible globally, especially in resource-limited areas.

Chitosan extraction from Amanita phalloides: yield, crystallinity, degree of deacetylation, azo dye removal and antibacterial properties

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Scientists successfully extracted chitosan, a useful natural polymer, from the death cap mushroom (Amanita phalloides). This chitosan showed excellent ability to remove blue dye from water and killed harmful bacteria effectively. The extraction method was efficient and eco-friendly, making it a promising solution for cleaning polluted water and developing antibacterial products.

Ultrasound-assisted extraction and antioxidant activity of polysaccharides from Tenebrio molitor

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Researchers successfully extracted beneficial compounds called polysaccharides from mealworms (Tenebrio molitor) using ultrasound waves, making the process faster and more efficient than traditional methods. These extracted polysaccharides demonstrated strong antioxidant properties, meaning they can help neutralize harmful free radicals in the body. The study shows that mealworm polysaccharides could be used as natural health supplements or food additives with health benefits comparable to or better than Vitamin C.

Soy Sauce Fermentation with Cordyceps militaris: Process Optimization and Functional Profiling

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Researchers created a new type of soy sauce using Cordyceps militaris fungus, which contains health-promoting compounds. Using scientific optimization techniques, they found the best conditions for fermentation, resulting in a soy sauce with much higher levels of cordycepin and other beneficial compounds compared to traditional soy sauce. This product offers both the familiar taste of soy sauce and added health benefits, potentially serving as a functional food that people can use daily.

Enhancement of Mycelial Growth and Antifungal Activity by Combining Fermentation Optimization and Genetic Engineering in Streptomyces pratensis S10

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Scientists improved a soil bacterium called Streptomyces pratensis S10 that fights a serious wheat disease called Fusarium head blight. They used two strategies: first, they optimized the growth medium using statistical methods to produce more bacteria with stronger antifungal powers, and second, they used genetic engineering to remove a gene that was limiting its disease-fighting ability. The result was a bacteria strain that is much more effective at controlling this crop disease.

Extraction, physicochemical properties, and antioxidant activity of natural melanin from Auricularia heimuer fermentation

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Researchers optimized a method to extract melanin, a natural black pigment, from fermented wood ear mushrooms (Auricularia heimuer). Using microwave-assisted extraction with specific pH conditions, they achieved a 0.4% yield of pure melanin. The extracted melanin showed strong antioxidant properties and could be used as a natural, safe colorant and antioxidant in food and pharmaceutical products.

Research Keyword: Box-Behnken design