bloodstream infection

mGem: Sepsis and antimicrobial resistance in the context of advanced HIV disease

mycolabadmin

This review examines how serious infections (sepsis) from bacteria and fungi affect people with advanced HIV disease, particularly in hospitals. The infections have become more dangerous due to antimicrobial resistance, and many cases go undiagnosed because of limited laboratory capabilities. The paper calls for better diagnostic tools and treatment strategies tailored to resource-limited settings where most advanced HIV disease cases occur.

Magnusiomyces capitatus bloodstream infection in a patient with acute monocytic leukemia: A rare case report

mycolabadmin

A 26-year-old patient with acute leukemia developed a serious fungal blood infection caused by Magnusiomyces capitatus, a rare organism found in environmental sources. The infection was confirmed using advanced molecular techniques and showed resistance to common antifungal drugs but responded to amphotericin B treatment. This case highlights how important it is for doctors to consider unusual fungi in severely immunocompromised patients and to use modern diagnostic methods for accurate identification and tailored treatment.

Epidemiology of Candidemia, Candiduria and Emerging Candidozyma (Candida) auris Across Gulf Cooperative Council Countries and Yemen in the Arabian Peninsula

mycolabadmin

This comprehensive review examines fungal bloodstream and urinary tract infections caused by Candida species across Middle Eastern countries. The study shows that while Candida albicans remains common, dangerous antibiotic-resistant strains like Candidozyma auris are increasingly appearing in hospitals. The research highlights that better diagnostic tools and infection prevention practices are urgently needed in the region to protect patients and reduce deaths from these serious infections.

Candida albicans bloodstream infections are comprised of diverse populations of strains, including antifungal tolerant strains that emerge during treatment failure

mycolabadmin

Researchers found that Candida albicans bloodstream infections contain multiple different strains, not just one strain as previously thought. Some strains are more tolerant to antifungal medications like micafungin, and when treatment is started, the drug-tolerant strains can be eliminated while drug-sensitive strains increase in number. This discovery suggests that treatment failures may occur because pre-existing drug-resistant strains are selected for during treatment.

Magnusiomyces capitatus bloodstream infection in a patient with acute monocytic leukemia: A rare case report

mycolabadmin

A 26-year-old patient with acute leukemia developed a rare fungal bloodstream infection caused by Magnusiomyces capitatus during cancer treatment. The infection was identified through advanced laboratory techniques including DNA sequencing and mass spectrometry. The patient was successfully treated with amphotericin B, highlighting the importance of rapid and accurate fungal identification for better patient outcomes.

Persistent Candidemia: Predictors and Outcomes in a Multicenter Matched Analysis

mycolabadmin

This study examined cases where fungal infections caused by Candida persisted in the bloodstream even after starting antifungal treatment. Researchers compared 46 patients with persistent infections to 92 control patients without persistent infections across three major medical centers. Patients with persistent candidemia were younger, more likely to be female, had more health complications, and sadly had much higher death rates (54% vs 31%) within 90 days. The findings suggest that certain patient characteristics and fungal species types may help identify those at higher risk of persistent infections.

Neonatal Invasive Candidiasis: Current Concepts

mycolabadmin

Serious fungal infections (candidiasis) in newborns have become increasingly difficult to treat, especially in developing countries. The types of fungi causing these infections have changed dramatically, with many now resisting the standard fluconazole treatment. Modern medical care, like proper handwashing, environmental cleaning, and careful line care, is actually more effective at preventing these infections than giving preventive antifungal drugs. Healthcare providers need better tools for quickly identifying which fungal species is causing infection and which drugs will work against it.

Clinical insights into mixed Candida and bacterial bloodstream infections: a retrospective cohort study

mycolabadmin

This study found that when both Candida fungus and bacteria are present together in a patient’s bloodstream, the outcome is much more serious than when only Candida is present. Among patients with these mixed infections, over 60% died within 30 days compared to about 52% for those with only Candida. The research shows that giving the right antibiotics early and following proper treatment guidelines can significantly improve survival chances in these severe, life-threatening infections.

Research Keyword: bloodstream infection