Biosynthetic pathways

Fungal Metabolomics: A Comprehensive Approach to Understanding Pathogenesis in Humans and Identifying Potential Therapeutics

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This review explains how scientists use metabolomics—a technique that identifies all chemical compounds in organisms—to understand how fungi cause disease and resist medicines. Fungi produce many different chemicals that help them attack our bodies and survive treatments, but these same chemicals could also be used to create new medicines. By studying these fungal chemicals, researchers can develop better antifungal drugs and understand how fungi manage to evade our immune system.

Advanced Fungal Biotechnologies in Accomplishing Sustainable Development Goals (SDGs): What Do We Know and What Comes Next?

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Fungi are remarkable organisms with tremendous untapped potential for solving global challenges. They can be engineered to produce life-saving medicines like antibiotics and cholesterol-lowering drugs, create nutritious food alternatives, clean up polluted environments, and help fight climate change. As we transition to more sustainable living practices, fungi represent a natural solution that has been used for centuries but is only now being fully appreciated through modern biotechnology.

Volatile Organic Compounds Produced by Co-Culture of Burkholderia vietnamiensis B418 with Trichoderma harzianum T11-W Exhibits Improved Antagonistic Activities against Fungal Phytopathogens

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Scientists studied how two beneficial microorganisms (a bacterium and a fungus) work together to produce compounds that kill plant-damaging fungi. When grown together, they produced more protective compounds than when grown separately, showing promise as a natural alternative to chemical fungicides for protecting crops and stored fruits from fungal diseases.

Whole genome sequencing and annotations of Trametes sanguinea ZHSJ

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Scientists have completely mapped the genetic code of Trametes sanguinea, a medicinal mushroom used in traditional Chinese medicine. They identified over 10,000 genes and analyzed how this mushroom produces compounds that fight tumors, boost immunity, protect the heart, and fight viruses. This genetic map will help researchers understand how to produce these beneficial compounds and develop new medicines from this mushroom.

Draft whole genome sequence of Alternaria alternata strain P02PL2, an endophytic fungal species isolated from Sclerocarya birrea

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Scientists sequenced the complete genetic blueprint of a beneficial fungus called Alternaria alternata that lives inside African marula tree leaves. This fungus produces many different bioactive compounds with potential medical applications. The genetic information is now publicly available for researchers to study how this fungus makes these useful compounds and develop new treatments.

Effects and molecular mechanism of endophytic elicitors on the accumulation of secondary metabolites in medicinal plants

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This review explains how beneficial fungi living inside medicinal plants can boost the production of healing compounds. These endophytic fungi act as natural triggers that activate the plant’s own defense systems, causing it to produce more of the valuable medicinal substances used in traditional and modern medicine. By understanding how this process works, scientists can develop better methods to grow medicinal plants and produce natural drugs more sustainably without depleting wild plant populations.

Identification of the High Mannose N-Glycan Isomers Undescribed by Conventional Multicellular Eukaryotic Biosynthetic Pathways

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Researchers developed a new method to identify the sugar structures attached to proteins in various foods and organisms. They discovered that many of these sugar structures are different from what scientists previously thought based on standard biological pathways. Using advanced mass spectrometry technology, they created a database to quickly identify these novel sugar structures, which could help better understand how organisms modify their proteins.

Discovery of the antifungal compound ilicicolin K through genetic activation of the ilicicolin biosynthetic pathway in Trichoderma reesei

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Scientists used genetic engineering to activate a dormant gene cluster in the fungus Trichoderma reesei, enabling it to produce the antifungal compound ilicicolin H in high quantities. During this process, they discovered a new related compound called ilicicolin K that shows even stronger antifungal properties. These compounds could potentially overcome limitations of current antifungal treatments, especially against drug-resistant fungi like Candida auris.

Influence of Culture Conditions on Bioactive Compounds in Cordyceps militaris: A Comprehensive Review

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Cordyceps militaris is a medicinal fungus used traditionally for treating fatigue, boosting immunity, and managing various health conditions. This comprehensive review explains how different growing methods, nutrients, light, temperature, and substrate materials affect the production of beneficial compounds in the fungus. The findings show that mixing grains with insect materials and using specific light conditions can significantly increase production of cordycepin, the most promising compound for cancer and immune health. The review identifies that more standardized growing methods and better understanding of the fungus’s metabolism are needed to make large-scale production practical and affordable.

Energy Metabolism Enhance Perylenequinone Biosynthesis in Shiraia sp. Slf14 through Promoting Mitochondrial ROS Accumulation

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Scientists studied two similar fungi to understand how one produces more of a beneficial compound called perylenequinones (PQs), which have medical uses against infections and cancer. They discovered that the high-producing strain uses energy more efficiently, which causes tiny structures in the cells called mitochondria to produce reactive molecules (ROS). These reactive molecules trigger the fungus to make more PQs as a protective response. By controlling these processes, researchers can potentially improve the production of this valuable medicine.

Research Keyword: Biosynthetic pathways