Research Keyword: biomarker identification

Untargeted metabolomics as a tool to assess the impact of dietary approaches on pig gut health: a review

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This review examines how different types of food and feed additives affect the chemical compounds in pig digestive systems. By analyzing thousands of tiny molecules in pig samples using advanced laboratory techniques, researchers can understand which dietary approaches help pigs maintain healthy guts and resist disease. The study shows that adjusting the levels of carbohydrates, proteins, and fats in pig feed can influence beneficial bacteria and protective compounds in their intestines.

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Optimized protein extraction protocol from human skin samples

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Researchers developed an improved method for extracting and analyzing proteins from human skin samples. Using specialized equipment and chemical treatments, they were able to identify about 6,000 different proteins in skin tissue, which is significantly more than previous methods could detect. This new protocol is particularly useful for studying skin diseases like fungal infections and could help identify new treatments by revealing how proteins change in diseased skin.

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Lectins as versatile tools to explore cellular glycosylation

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Lectins are natural proteins that selectively bind to sugars on cell surfaces, discovered over 130 years ago as tools for studying cell chemistry. They have become especially valuable in cancer research, revealing how cancer cells have abnormal sugar patterns that predict how aggressively they spread. Modern biotechnology now allows scientists to create enhanced lectin versions and use them in high-throughput screening to discover new disease markers and improve patient diagnosis.

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Metabolomics analysis of mycelial exudates provides insights into fungal antagonists of Armillaria

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This study examined how two types of honey mushrooms (Armillaria) fight each other when grown together. Researchers found specific chemical markers and metabolic pathways that are activated during this competition. The study identified 156 new compounds produced during co-culture, including 32 with potential antifungal properties. These findings could help understand how mushrooms naturally combat fungal pathogens.

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