Research Keyword: bioavailability enhancement

Overcoming Solubility Challenges: Micronization of Berberine Using the GAS Antisolvent Technique

Berberine is a traditional medicinal compound that could treat many diseases but doesn’t work well in the body because it doesn’t dissolve in water. Researchers used a special technique with pressurized carbon dioxide to break berberine into much smaller particles. This made the particles dissolve 18% better in water, which could make berberine-based medicines more effective at treating diabetes, high cholesterol, and other conditions.

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Integration of active ingredients from traditional Chinese medicine with nano-delivery systems for tumor immunotherapy

This review examines how traditional Chinese medicine ingredients can boost the body’s natural ability to fight cancer when combined with tiny nanoparticles that deliver drugs more effectively. The nanoparticles help TCM compounds work better by improving how they dissolve, how long they stay in the body, and where they target. By activating immune cells like natural killer cells and dendritic cells while reducing immune-suppressing cells, this combination approach offers a promising new strategy for cancer treatment with fewer side effects.

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Nanomaterial-mediated strategies for enhancing bioremediation of polycyclic aromatic hydrocarbons: A systematic review

This review examines how combining tiny engineered materials (nanomaterials) with natural microorganisms can more effectively clean up environmental pollution from polycyclic aromatic hydrocarbons, which are harmful chemicals produced by burning fossil fuels and other processes. The study found that using nanomaterials alongside bacteria significantly improved pollution removal rates in water and soil, with improvements of up to 19% in liquid samples and 14% in soil samples. Different types of nanomaterials like carbon-based materials and metal oxides work by helping bacteria degrade pollutants more efficiently through various mechanisms. This approach offers a more sustainable and environmentally friendly solution compared to using traditional remediation methods alone.

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Design and Evaluation of a Inonotus obliquus–AgNP–Maltodextrin Delivery System: Antioxidant, Antimicrobial, Acetylcholinesterase Inhibitory and Cytotoxic Potential

Researchers studied Chaga mushroom from Romania and developed new ways to package and deliver its beneficial compounds using silver nanoparticles and a food-safe ingredient called maltodextrin. These new delivery systems were designed to work better in the body by improving how well the mushroom’s active ingredients dissolve and stay stable. Testing showed these enhanced formulations were very effective at fighting bacteria, protecting cells from damage, and killing cancer cells.

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